3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

Richard Elliott (Inventor), Alan Ashworth (Inventor), Christopher J Lord (Inventor), Dan Niculescu-Duvaz (Inventor), Roderick Porter (Inventor), Raymond Boffey (Inventor), Melanie Bayford (Inventor), Stuart Firth-Clark (Inventor), Ashley Jarvis (Inventor), Trevor R Perrior (Inventor), Rebecca Key (Inventor)

Research output: Patent

Abstract

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted- 2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.) and/or Wnt signalling. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to inhibit Wnt signalling; to treat disorders that are ameliorated by the inhibition of PARP (e.g., PARP1, TNKS1, TNKS2, etc.); to treat disorders that are ameliorated by the inhibition of Wnt signalling; to treat proliferative conditions such as cancer, etc.
(FR) La présente invention concerne d'une manière générale le domaine des composés thérapeutiques. Plus spécifiquement, la présente invention se rapporte à certains composés 3-aryl -5-substitué -2 H-isoquinolin -1-one qui, entre autres, inhibent PARP (par exemple, PARP1, TNKS1, TNKS2, etc.) et/ou de signalisation Wnt. La présente invention concerne également des compositions pharmaceutiques comprenant ces composés à la fois in vitro et in vivo pour inhiber la signalisation Wnt afin de traiter des troubles qui sont améliorés par l'inhibition de PARP (par exemple, PARP1, TNKS1, TNKS2, etc.), de traiter des troubles qui sont améliorés par l'inhibition de la signalisation Wnt et de traiter des états prolifératifs tels que le cancer, etc.
Original languageEnglish
Patent numberWO2013132253
IPCA61P 35/00 (2006.01) ,A61K 31/472 (2006.01) ,C07D 401/14 (2006.01) ,C07D 217/14 (2006.01) ,C07D 217/16 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/10 (2006.01) ,C07D 401/12 (2006.01) ,C07D 405/12 (2006.01) ,C07D 487/04 (2006.01) ,C07D 487/08 (2006.01) ,C07D 487/10 (2006.01) ,A61K 31/4725 (2006.01) ,A61K 31/496 (2006.01) ,A61K 31/506 (2006.01)
Priority date7/03/12
Filing date7/03/13
Publication statusPublished - 12 Sep 2013

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