Projects per year
Abstract / Description of output
Sample preparation is a critical requirement for many clinical tests and diagnostic procedures, but it is difficult to perform on a lab-on-a-chip platform. The analytical side of microfluidic technologies has been gradually catching up with laboratory methods in terms of sensitivity, selectivity, and reliability. There is a growing need for the development of sample preparation modules that can either be connected or embedded into such devices and extract blood plasma in a fast, safe, and automated way. Achieving this functionality is an important step towards creating commercially viable products that can one day become part of everyday life. In this study, a range of simple, yet effective, 3D printed sample preparation devices was developed. The devices rely on snap-fit mechanisms and "resin-bonding" methods to fasten two layers and integrate a plasma separation membrane in between. The devices have excellent usability, with only one step required for their operation without any waiting time for the user, and could extract an average of 56.88% of the total available plasma from 50 μL capillary blood samples in 87 s without inducing any haemolysis. The manufacturing process is quick and straightforward, requiring only low-cost equipment and minimal training. The devices can either be used as a stand-alone device or integrated into an existing lab-on-a-chip system to provide blood filtration capabilities.
Original language | English |
---|---|
Article number | 359 |
Number of pages | 14 |
Journal | Micromachines |
Volume | 15 |
Issue number | 3 |
Early online date | 29 Feb 2024 |
DOIs | |
Publication status | Published - Mar 2024 |
Keywords / Materials (for Non-textual outputs)
- 3D printing
- cell separation
- microfiltration
- point of care testing
- sample preparation
Fingerprint
Dive into the research topics of '3D Printed Devices for the Separation of Blood Plasma from Capillary Samples'. Together they form a unique fingerprint.Projects
- 1 Finished
-
CDT-ISM: EPSRC Centre for Doctoral Training in Intelligent Sensing and Mesurementy
Harvey, A., Underwood, I., Walton, A. & Mount, A.
1/04/14 → 15/09/23
Project: Research
Datasets
-
Data for publication "3D Printed Devices for the Separation of Blood Plasma from Capillary Samples"
Deiana, G. (Creator), Edinburgh DataShare, 22 Mar 2024
DOI: 10.7488/ds/7695
Dataset