3D-printed electrospinning setup for the preparation of loratadine nanofibers with enhanced physicochemical properties

Rita Ambrus, Areen Alshweiat, Ildiko Csoka, George Ovari, Ammar Esmail, Norbert Radacsi

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigates the effects of drug-loaded nanofibers on the solubility of the poorly water-soluble drug, loratadine. Amorphous morphologies of electrospun loratadine nanofibers were prepared using a low-cost 3D-printed electrospinning setup with counter-flow air for the rapid production of nanofibers . Polyvinylpyrrolidone was used as a carrier polymer and ethanol as a solvent in the solution preparation. The prepared nanofibers were characterized by scanning electron microscopy, differential scanning calorimetry, X-ray diffraction analysis, Fourier transform infrared spectroscopy, solubility and in vitro dissolution studies with kinetic behavior evaluation. The scanning electron microscope images showed smooth nanofiber surfaces with a mean diameter of 372 nm. Moreover, both differential scanning calorimetry and X-ray diffraction analysis confirmed the amorphous state of the prepared nanofibers. FT-IR results suggested that loratadine lost its original crystal structure by hydrogen bonding interactions. The fabricated nanofibrous drug samples demonstrated a remarkable 26-fold increase in solubility when compared to the pure drug in phosphate buffer at pH 7.4. Furthermore, dissolution studies showed that 66% of the drug from the nanofibrous mat was released in the first 10 min, which is significantly higher than the maximum of 4% drug release of the reference samples within the same time. Thus, Loratadine nanofibers can be considered as an alternative dosage form with improved physicochemical properties.
Original languageEnglish
Article number118455
JournalInternational Journal of Pharmaceutics
Volume567
Early online date21 Jun 2019
DOIs
Publication statusE-pub ahead of print - 21 Jun 2019

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