5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

CHENYING Yang, M Nixon, C J Kenyon, D E W Livingstone, R Duffin, A G Rossi, B R Walker, R Andrew

Research output: Contribution to journalArticlepeer-review

Abstract

Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo.
Original languageEnglish
Pages (from-to)1661-71
Number of pages11
JournalBritish Journal of Pharmacology
Volume164
Issue number6
DOIs
Publication statusPublished - 2011

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