5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

CHENYING Yang; M Nixon; C J Kenyon; D E W Livingstone; R Duffin; A G Rossi; B R Walker; R Andrew

doi:10.1111/j.1476-5381.2011.01465.x

5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

CHENYING Yang
, M Nixon
, C J Kenyon
, D E W Livingstone
, R Duffin
, A G Rossi
, B R Walker
, R Andrew

Research output: Contribution to journal › Article › peer-review

Abstract

Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo.

Original language	English
Pages (from-to)	1661-71
Number of pages	11
Journal	British Journal of Pharmacology
Volume	164
Issue number	6
DOIs	https://doi.org/10.1111/j.1476-5381.2011.01465.x
Publication status	Published - 2011

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10.1111/j.1476-5381.2011.01465.x

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01465.x/abstract

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research
Tissue specific determinants of glucocorticoid signalling in humans - new mechanisms and therapies for cardiovascular risk. (Renewal: YYRS 11-15)
Walker, B. (Principal Investigator)
UK-based charities
1/04/11 → 31/03/16
Project: Research
Induction of neutrophil apoptosis and treatment of severe lung inflammation
Rossi, A. (Principal Investigator)
MRC
1/09/07 → 29/02/12
Project: Research

Cite this

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title = "5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects",

abstract = "Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo.",

author = "CHENYING Yang and M Nixon and Kenyon, \{C J\} and Livingstone, \{D E W\} and R Duffin and Rossi, \{A G\} and Walker, \{B R\} and R Andrew",

note = "{\textcopyright} 2011 The Authors. British Journal of Pharmacology {\textcopyright} 2011 The British Pharmacological Society.",

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doi = "10.1111/j.1476-5381.2011.01465.x",

language = "English",

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T1 - 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

AU - Yang, CHENYING

AU - Nixon, M

AU - Kenyon, C J

AU - Livingstone, D E W

AU - Duffin, R

AU - Rossi, A G

AU - Walker, B R

AU - Andrew, R

PY - 2011

Y1 - 2011

N2 - Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo.

AB - Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study compares the effects of 5αTHB on inflammation and metabolism in vitro and in vivo.

U2 - 10.1111/j.1476-5381.2011.01465.x

DO - 10.1111/j.1476-5381.2011.01465.x

M3 - Article

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SN - 1476-5381

VL - 164

SP - 1661

EP - 1671

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 6

ER -

5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

Abstract

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Projects

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Tissue specific determinants of glucocorticoid signalling in humans - new mechanisms and therapies for cardiovascular risk. (Renewal: YYRS 11-15)

Induction of neutrophil apoptosis and treatment of severe lung inflammation

Cite this