99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Induction and control of regulatory T cells in the gastrointestinal tract: consequences for local and peripheral immune responses

Y. Belkaid, O. Liesenfeld, R. M. Maizels

Research output: Contribution to journalArticlepeer-review

Abstract

P>Regulatory T cells play a crucial role in normal gut homeostasis, as well as during infection with microbial or parasitic pathogens. Prior to infection, interactions with the commensal microflora are essential to differentiation of a healthy steady-state level of immunoregulation, mediated through both Toll-like receptor-dependent and -independent pathways. The ingress of pathogenic organisms may, according to the context, promote or reverse the regulatory environment, with onward consequences for inflammation in both the intestinal and extra-intestinal settings. Appropriate regulation of gut immunity thus depends upon a complex three-way interplay between host cells, commensals and pathogens, and can exert a major impact on systemic responses including allergy and autoimmunity.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalClinical & Experimental Immunology
Volume160
Issue number1
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Colitis,
  • helminths,
  • inflammatory bowel disease
  • microbiome,
  • protozoa

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