Projects per year
Abstract
However, while identifying cyclically expressed genes from time series measurements is relatively easy, determining the structure of the interaction network underpinning the oscillation is a far more challenging problem. Results: Here, we explicitly leverage the oscillatory nature of the transcriptional signals and present a method for reconstructing network interactions tailored to this special but important class of genetic circuits. Our method is based on projecting the signal onto a set of oscillatory basis functions using a Discrete Fourier Transform. We build a Bayesian Hierarchical model within a frequency domain linear model in order to enforce sparsity and incorporate prior knowledge about the network structure. Experiments on real and simulated data show that the method can lead to substantial improvements over competing approaches if the oscillatory assumption is met, and remains competitive also in cases it is not.
Original language | English |
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Pages (from-to) | 3617-3624 |
Number of pages | 8 |
Journal | Bioinformatics |
Volume | 31 |
Issue number | 22 |
DOIs | |
Publication status | Published - 14 Jul 2015 |
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Dive into the research topics of 'A Bayesian approach for structure learning in oscillating regulatory networks'. Together they form a unique fingerprint.Projects
- 2 Finished
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SynthSys-Mammalian: Edinburgh Mammalian Synthetic Biology Research Centre
Rosser, S., Bird, A., Cai, Y., Earnshaw, B., Millar, A., Molina, N., Pilizota, T., Swain, P. & Waites, W.
14/11/14 → 31/03/22
Project: Research
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MLCS - Machine learning for computational science statistical and formal modeling of biological systems
Sanguinetti, G.
1/10/12 → 30/09/17
Project: Research
Datasets
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Data, Code and Models for Flis et al. RS Open Biology 2015
Millar, A. (Creator), Zielinski, T. (Data Manager), Flis, A. (Creator), Mengin, V. (Creator), Stitt, M. (Creator), Fernández, A. P. (Creator), McWatters, H. G. (Creator) & Halliday, K. (Creator), The Royal Society, 2015
https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611467827 and 30 more links, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820610743262, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611319996, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611188065, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611587928, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820606741450, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820610913763, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228354371807, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12962296599986, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12962294335805, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2841, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2842, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2843 , https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228298288040, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13227619871305, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228357183121, http://sourceforge.net/projects/biodare/, http://www.biodare.ed.ac.uk, http://sourceforge.net/projects/sbsi/, http://www.sbsi.ed.ac.uk, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_71&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_71&version=2, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1041&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1042&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1043&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1044&version=1, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13227622661196, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228357183121, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=3488, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=3492, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1045&version=1 (show fewer)
Dataset