Activities per year
Abstract / Description of output
Heterochronous data sets comprise molecular sequences sampled at different points in time. If the temporal range of the sampled sequences is large relative to the rate of mutation, the sampling times can directly calibrate evolutionary rates to calendar time. Here, we extend this calibration process to provide a full probabilistic method that utilizes temporal information in heterochronous data sets to estimate sampling times (leaf-ages) for sequenced for which this information unavailable. Our method is similar to relaxing the constraints of the molecular clock on specific lineages within a phylogenetic tree. Using a combination of synthetic and empirical data sets, we demonstrate that the method estimates leaf-ages reliably and accurately. Potential applications of our approach include incorporating samples of uncertain or radiocarbon-infinite age into ancient DNA analyses, evaluating the temporal signal in a particular sequence or data set, and exploring the reliability of sequence ages that are somehow contentious.
Original language | English |
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Pages (from-to) | 879-887 |
Number of pages | 9 |
Journal | Molecular Biology and Evolution |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2011 |
Keywords / Materials (for Non-textual outputs)
- heterochronous sequences
- ancient DNA
- molecular clock
- viral evolution
- measurably evolving populations
- ANCIENT DNA
- POPULATION-DYNAMICS
- MOLECULAR EVOLUTION
- INFLUENZA-VIRUS
- CLIMATIC-CHANGE
- BROWN BEARS
- PLEISTOCENE
- HIV-1
- RATES
- EXTINCTION
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Dive into the research topics of 'A Bayesian Phylogenetic Method to Estimate Unknown Sequence Ages'. Together they form a unique fingerprint.Activities
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NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr (External organisation)
Andrew Rambaut (Member)
Sept 2009 → Aug 2015Activity: Membership types › Membership of external research organisation
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NESCENT Working Group meeting on Software for Bayesian Evolutionary Analysis by Sampling Trees
Andrew Rambaut (Organiser)
2009 → 2013Activity: Participating in or organising an event types › Participation in workshop, seminar, course