A brainwide atlas of synapses across the mouse life span

Mélissa Cizeron; Zhen Qiu; Babis Koniaris; Ragini Gokhale; Noboru H. Komiyama; Erik Fransén; Seth G. N. Grant

doi:10.1126/science.aba3163

A brainwide atlas of synapses across the mouse life span

Mélissa Cizeron, Zhen Qiu, Babis Koniaris, Ragini Gokhale, Noboru H. Komiyama, Erik Fransén, Seth G. N. Grant

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, and susceptibility to behavioral disorders.

*NOTE: Mélissa Cizeron and Zhen Qiu contributed equally.

Original language	English
Pages (from-to)	270-275
Number of pages	6
Journal	Science
Volume	369
Issue number	6501
Early online date	11 Jun 2020
DOIs	https://doi.org/10.1126/science.aba3163
Publication status	Published - 17 Jul 2020

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10.1126/science.aba3163Licence: Other

Grant- Lifespan SCIENCE manuscript 2020
This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 11th June 2020, DOI: 10.1126/science.aba3163.
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http://science.sciencemag.org/cgi/content/full/science.aba3163?ijkey=O2OfBJ.Rc5Vmk&keytype=ref&siteid=sci Licence: Other

Lab and animal colony management
McLaughlin, C.
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Seth Grant
- seth.granted.acuk
- Deanery of Clinical Sciences - Personal Chair of Molecular Neuroscience
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
Person: Academic: Research Active

Cite this

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title = "A brainwide atlas of synapses across the mouse life span",

abstract = "Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, and susceptibility to behavioral disorders.*NOTE: M{\'e}lissa Cizeron and Zhen Qiu contributed equally.",

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AU - Qiu, Zhen

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AU - Komiyama, Noboru H.

AU - Fransén, Erik

AU - Grant, Seth G. N.

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A brainwide atlas of synapses across the mouse life span

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