Giovanni Pisano carved animal tracks on the base of one of two lions bearing columns in his pulpit for Pisa Cathedral (1302-1310). Overlooked for more than seven centuries, these are the first naturalistic paw prints carved in marble in post-Classical Western art. This paper presents the initial results of a joint art historical and anatomical study of the Pisa paw prints conducted by Dr Luca Palozzi and Dr Gurå Bergkvist. In so doing, it tackles the much-debated issue of Medieval ‘naturalism’ (and its means) from an unusual perspective. A cross-disciplinary approach, that is, may help us find new answers to long-standing questions.