A call for transparent reporting to optimize the predictive value of preclinical research

Story C. Landis; Susan G. Amara; Khusru Asadullah; Chris P. Austin; Robi Blumenstein; Eileen W. Bradley; Ronald G. Crystal; Robert B. Darnell; Robert J. Ferrante; Howard Fillit; Robert Finkelstein; Marc Fisher; Howard E. Gendelman; Robert M. Golub; John L. Goudreau; Robert A. Gross; Amelie K. Gubitz; Sharon E. Hesterlee; David W. Howells; John Huguenard; Katrina Kelner; Walter Koroshetz; Dimitri Krainc; Stanley E. Lazic; Michael S. Levine; Malcolm R. Macleod; John M. McCall; Richard T. Moxley; Kalyani Narasimhan; Linda J. Noble; Steve Perrin; John D. Porter; Oswald Steward; Ellis Unger; Ursula Utz; Shai D. Silberberg

doi:10.1038/nature11556

A call for transparent reporting to optimize the predictive value of preclinical research

Story C. Landis, Susan G. Amara, Khusru Asadullah, Chris P. Austin, Robi Blumenstein, Eileen W. Bradley, Ronald G. Crystal, Robert B. Darnell, Robert J. Ferrante, Howard Fillit, Robert Finkelstein, Marc Fisher, Howard E. Gendelman, Robert M. Golub, John L. Goudreau, Robert A. Gross, Amelie K. Gubitz, Sharon E. Hesterlee, David W. Howells, John HuguenardKatrina Kelner, Walter Koroshetz, Dimitri Krainc, Stanley E. Lazic, Michael S. Levine, Malcolm R. Macleod, John M. McCall, Richard T. Moxley, Kalyani Narasimhan, Linda J. Noble, Steve Perrin, John D. Porter, Oswald Steward, Ellis Unger, Ursula Utz, Shai D. Silberberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	Nature
Volume	490
Issue number	7419
DOIs	https://doi.org/10.1038/nature11556
Publication status	Published - 11 Oct 2012

Keywords / Materials (for Non-textual outputs)

PUBLICATION BIAS
EXPERIMENTAL STROKE
CONTROLLED CLINICAL-TRIALS
RANDOMIZED CONTROLLED-TRIALS
CONSORT STATEMENT
CANCER-RESEARCH
ANIMAL RESEARCH
EMPIRICAL-EVIDENCE
DRUG DEVELOPMENT
STATISTICAL-ANALYSIS

Access to Document

10.1038/nature11556

A call for transparent reporting to optimize the predictive value of preclinical researchAccepted author manuscript, 50.3 KB

http://www.nature.com/nature/journal/v490/n7419/full/nature11556.html

Cite this

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., Finkelstein, R., Fisher, M., Gendelman, H. E., Golub, R. M., Goudreau, J. L., Gross, R. A., Gubitz, A. K., Hesterlee, S. E., Howells, D. W., ... Silberberg, S. D. (2012). A call for transparent reporting to optimize the predictive value of preclinical research. Nature, 490(7419), 187-191. https://doi.org/10.1038/nature11556

@article{e484491a86c0432084f0b4072e367971,

title = "A call for transparent reporting to optimize the predictive value of preclinical research",

abstract = "The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.",

keywords = "PUBLICATION BIAS, EXPERIMENTAL STROKE, CONTROLLED CLINICAL-TRIALS, RANDOMIZED CONTROLLED-TRIALS, CONSORT STATEMENT, CANCER-RESEARCH, ANIMAL RESEARCH, EMPIRICAL-EVIDENCE, DRUG DEVELOPMENT, STATISTICAL-ANALYSIS",

author = "Landis, {Story C.} and Amara, {Susan G.} and Khusru Asadullah and Austin, {Chris P.} and Robi Blumenstein and Bradley, {Eileen W.} and Crystal, {Ronald G.} and Darnell, {Robert B.} and Ferrante, {Robert J.} and Howard Fillit and Robert Finkelstein and Marc Fisher and Gendelman, {Howard E.} and Golub, {Robert M.} and Goudreau, {John L.} and Gross, {Robert A.} and Gubitz, {Amelie K.} and Hesterlee, {Sharon E.} and Howells, {David W.} and John Huguenard and Katrina Kelner and Walter Koroshetz and Dimitri Krainc and Lazic, {Stanley E.} and Levine, {Michael S.} and Macleod, {Malcolm R.} and McCall, {John M.} and Moxley, {Richard T.} and Kalyani Narasimhan and Noble, {Linda J.} and Steve Perrin and Porter, {John D.} and Oswald Steward and Ellis Unger and Ursula Utz and Silberberg, {Shai D.}",

year = "2012",

month = oct,

day = "11",

doi = "10.1038/nature11556",

language = "English",

volume = "490",

pages = "187--191",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7419",

}

Landis, SC, Amara, SG, Asadullah, K, Austin, CP, Blumenstein, R, Bradley, EW, Crystal, RG, Darnell, RB, Ferrante, RJ, Fillit, H, Finkelstein, R, Fisher, M, Gendelman, HE, Golub, RM, Goudreau, JL, Gross, RA, Gubitz, AK, Hesterlee, SE, Howells, DW, Huguenard, J, Kelner, K, Koroshetz, W, Krainc, D, Lazic, SE, Levine, MS, Macleod, MR, McCall, JM, Moxley, RT, Narasimhan, K, Noble, LJ, Perrin, S, Porter, JD, Steward, O, Unger, E, Utz, U & Silberberg, SD 2012, 'A call for transparent reporting to optimize the predictive value of preclinical research', Nature, vol. 490, no. 7419, pp. 187-191. https://doi.org/10.1038/nature11556

TY - JOUR

T1 - A call for transparent reporting to optimize the predictive value of preclinical research

AU - Landis, Story C.

AU - Amara, Susan G.

AU - Asadullah, Khusru

AU - Austin, Chris P.

AU - Blumenstein, Robi

AU - Bradley, Eileen W.

AU - Crystal, Ronald G.

AU - Darnell, Robert B.

AU - Ferrante, Robert J.

AU - Fillit, Howard

AU - Finkelstein, Robert

AU - Fisher, Marc

AU - Gendelman, Howard E.

AU - Golub, Robert M.

AU - Goudreau, John L.

AU - Gross, Robert A.

AU - Gubitz, Amelie K.

AU - Hesterlee, Sharon E.

AU - Howells, David W.

AU - Huguenard, John

AU - Kelner, Katrina

AU - Koroshetz, Walter

AU - Krainc, Dimitri

AU - Lazic, Stanley E.

AU - Levine, Michael S.

AU - Macleod, Malcolm R.

AU - McCall, John M.

AU - Moxley, Richard T.

AU - Narasimhan, Kalyani

AU - Noble, Linda J.

AU - Perrin, Steve

AU - Porter, John D.

AU - Steward, Oswald

AU - Unger, Ellis

AU - Utz, Ursula

AU - Silberberg, Shai D.

PY - 2012/10/11

Y1 - 2012/10/11

N2 - The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

AB - The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

KW - PUBLICATION BIAS

KW - EXPERIMENTAL STROKE

KW - CONTROLLED CLINICAL-TRIALS

KW - RANDOMIZED CONTROLLED-TRIALS

KW - CONSORT STATEMENT

KW - CANCER-RESEARCH

KW - ANIMAL RESEARCH

KW - EMPIRICAL-EVIDENCE

KW - DRUG DEVELOPMENT

KW - STATISTICAL-ANALYSIS

U2 - 10.1038/nature11556

DO - 10.1038/nature11556

M3 - Article

SN - 0028-0836

VL - 490

SP - 187

EP - 191

JO - Nature

JF - Nature

IS - 7419

ER -

A call for transparent reporting to optimize the predictive value of preclinical research

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this