A case of membranous nephropathy with microspherular deposits progressing to collapsing nephropathy and dialysis dependency, but with full recovery following immunosuppression

Matthew Sayer; Samuel Pattle; Paul J Phelan; Christopher O C Bellamy

doi:10.5414/CN110998

A case of membranous nephropathy with microspherular deposits progressing to collapsing nephropathy and dialysis dependency, but with full recovery following immunosuppression

Matthew Sayer, Samuel Pattle, Paul J Phelan, Christopher O C Bellamy

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case presenting with severe nephrotic syndrome and pathological features of collapsing glomerulopathy. This is the first case we are aware of that progressed to requiring dialysis. The patient received rituximab and corticosteroids. She has now been off dialysis for over a year with both serum creatinine and urine protein-creatinine ratio returning to baseline.

Original language	English
Pages (from-to)	191-196
Number of pages	6
Journal	Clinical Nephrology
Volume	99
Issue number	4
DOIs	https://doi.org/10.5414/CN110998
Publication status	Published - 1 Apr 2023

Keywords / Materials (for Non-textual outputs)

Female
Humans
Glomerulonephritis, Membranous/diagnosis
Renal Dialysis
Kidney/pathology
Nephrotic Syndrome/diagnosis
Kidney Diseases/pathology
Immunosuppression Therapy

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10.5414/CN110998

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title = "A case of membranous nephropathy with microspherular deposits progressing to collapsing nephropathy and dialysis dependency, but with full recovery following immunosuppression",

abstract = "Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case presenting with severe nephrotic syndrome and pathological features of collapsing glomerulopathy. This is the first case we are aware of that progressed to requiring dialysis. The patient received rituximab and corticosteroids. She has now been off dialysis for over a year with both serum creatinine and urine protein-creatinine ratio returning to baseline.",

keywords = "Female, Humans, Glomerulonephritis, Membranous/diagnosis, Renal Dialysis, Kidney/pathology, Nephrotic Syndrome/diagnosis, Kidney Diseases/pathology, Immunosuppression Therapy",

author = "Matthew Sayer and Samuel Pattle and Phelan, {Paul J} and Bellamy, {Christopher O C}",

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AU - Pattle, Samuel

AU - Phelan, Paul J

AU - Bellamy, Christopher O C

PY - 2023/4/1

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N2 - Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case presenting with severe nephrotic syndrome and pathological features of collapsing glomerulopathy. This is the first case we are aware of that progressed to requiring dialysis. The patient received rituximab and corticosteroids. She has now been off dialysis for over a year with both serum creatinine and urine protein-creatinine ratio returning to baseline.

AB - Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case presenting with severe nephrotic syndrome and pathological features of collapsing glomerulopathy. This is the first case we are aware of that progressed to requiring dialysis. The patient received rituximab and corticosteroids. She has now been off dialysis for over a year with both serum creatinine and urine protein-creatinine ratio returning to baseline.

KW - Female

KW - Humans

KW - Glomerulonephritis, Membranous/diagnosis

KW - Renal Dialysis

KW - Kidney/pathology

KW - Nephrotic Syndrome/diagnosis

KW - Kidney Diseases/pathology

KW - Immunosuppression Therapy

U2 - 10.5414/CN110998

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JO - Clinical Nephrology

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IS - 4

ER -

A case of membranous nephropathy with microspherular deposits progressing to collapsing nephropathy and dialysis dependency, but with full recovery following immunosuppression

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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