A Catalytic Asymmetric Borono Variant of Hosomi-Sakurai Reactions with N,O-Aminals

Yi-Yong Huang, Ananya Chakrabarti, Naohide Morita, Uwe Schneider, Shu Kobayashi

Research output: Contribution to journalArticlepeer-review

Abstract

Aminal attraction: The combination of indium(I) chloride and a chiral silver binol phosphate provides an excellent catalyst for asymmetric Hosomi–Sakurai reactions between N,O-aminals and boronates (see scheme; PG=protecting group, pin=pinacolato). The substrate scope includes aromatic, heteroaromatic, and aliphatic N,O-aminals as well as allyl and allenyl boronates.
Original languageEnglish
Pages (from-to)11121-11124
Number of pages4
JournalAngewandte Chemie International Edition
Volume50
Issue number47
DOIs
Publication statusPublished - Nov 2011

Keywords

  • asymmetric catalysis
  • boron
  • chiral counteranion
  • Hosomi–Sakurai reaction
  • indium

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