A cephalometric comparison of patients with the sleep apnea/hypopnea syndrome and their siblings

RL Riha*, P Brander, M Vennelle, NJ Douglas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Study Objectives: To define differences in the skeletal components of facial structure predisposing to the obstructive sleep apnea/hypopnea syndrome (OSAHS) by a comparison of the craniofacial complex between people with OSAHS and their siblings without OSAHS. Design: Case-control study using sibling pairs.

Setting: Scottish Sleep Centre.

Participants: 104 patients with OSAHS living in Scotland and 107 of their siblings.

Interventions: All subjects had sleep studies, clinical review, and cephalometry performed. All measurements were scored blind to index or control status.

Measurements and Results: 207 cephalograms were available for analysis, of which 145 were for dentate subjects (90 with definite OSAHS; 55 without). In the dentate subjects, regression analysis (correcting for body mass index and age) showed OSAHS was associated with a significantly longer distance from the hyoid bone to the mandibular plane in men (P = .02) and in women (P = .036). Regression analysis in 22 pairs of dentate brothers, discordant for the diagnosis of OSAHS (controlling for age and body mass index), showed a shorter mandibular corpus (P = .013) and lower hyoid in relation to the mandibular plane (P = .006) to be significantly associated with a diagnosis of OSAHS.

Conclusions: Men and women with OSAHS have a lower-set hyoid bone than do those without OSAHS. This occurs independently of obesity and remains even when intersubject variance is minimized by performing pair-wise comparison of the craniofacial complex between siblings with and without OSAHS.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
Issue number3
Publication statusPublished - 1 Mar 2005

Keywords / Materials (for Non-textual outputs)

  • cephalometry
  • obstructive sleep apnea/hypopnea syndrome
  • siblings
  • AGE


Dive into the research topics of 'A cephalometric comparison of patients with the sleep apnea/hypopnea syndrome and their siblings'. Together they form a unique fingerprint.

Cite this