Study Objectives: To define differences in the skeletal components of facial structure predisposing to the obstructive sleep apnea/hypopnea syndrome (OSAHS) by a comparison of the craniofacial complex between people with OSAHS and their siblings without OSAHS. Design: Case-control study using sibling pairs.
Setting: Scottish Sleep Centre.
Participants: 104 patients with OSAHS living in Scotland and 107 of their siblings.
Interventions: All subjects had sleep studies, clinical review, and cephalometry performed. All measurements were scored blind to index or control status.
Measurements and Results: 207 cephalograms were available for analysis, of which 145 were for dentate subjects (90 with definite OSAHS; 55 without). In the dentate subjects, regression analysis (correcting for body mass index and age) showed OSAHS was associated with a significantly longer distance from the hyoid bone to the mandibular plane in men (P = .02) and in women (P = .036). Regression analysis in 22 pairs of dentate brothers, discordant for the diagnosis of OSAHS (controlling for age and body mass index), showed a shorter mandibular corpus (P = .013) and lower hyoid in relation to the mandibular plane (P = .006) to be significantly associated with a diagnosis of OSAHS.
Conclusions: Men and women with OSAHS have a lower-set hyoid bone than do those without OSAHS. This occurs independently of obesity and remains even when intersubject variance is minimized by performing pair-wise comparison of the craniofacial complex between siblings with and without OSAHS.
|Number of pages||6|
|Publication status||Published - 1 Mar 2005|
- obstructive sleep apnea/hypopnea syndrome
- APNEA HYPOPNEA SYNDROME
- SNORING PATIENTS