TY - GEN
T1 - A CMOS-based lab-on-chip array for the combined magnetic stimulation and opto-chemical sensing of neural tissue
AU - Constandinou, Timothy G.
AU - Georgiou, Pantelis
AU - Prodromakis, Themistoklis
AU - Toumazou, Chris
PY - 2010/3/29
Y1 - 2010/3/29
N2 - This paper presents a novel CMOS-based labon-chip platform for non-contact magnetic stimulation and recording of neural tissue. The proposed system is the first of its kind to integrate magnetic-stimulation and optochemical sensing in a single pixel, tesselated to form an 8×8 array. Fabricated in a commercially-available 0.35μm CMOS technology, the system can be intrinsically used for both optical imaging and pH sensing and includes mechanisms for calibrating out sensor variation and mismatch. In addition to sensory acquisition via an integrated 10-bit ADC, a 64-instruction spatiotemporal pattern generator has been embedded within the array for driving the microscale magnetic neural stimulation. In this application the ISFET-based sensors are used to capacitively-couple neuronal charge in close proximity to the floating gate. Optical imaging hardware has also been embedded to provide topographic detail of the neural tissue.
AB - This paper presents a novel CMOS-based labon-chip platform for non-contact magnetic stimulation and recording of neural tissue. The proposed system is the first of its kind to integrate magnetic-stimulation and optochemical sensing in a single pixel, tesselated to form an 8×8 array. Fabricated in a commercially-available 0.35μm CMOS technology, the system can be intrinsically used for both optical imaging and pH sensing and includes mechanisms for calibrating out sensor variation and mismatch. In addition to sensory acquisition via an integrated 10-bit ADC, a 64-instruction spatiotemporal pattern generator has been embedded within the array for driving the microscale magnetic neural stimulation. In this application the ISFET-based sensors are used to capacitively-couple neuronal charge in close proximity to the floating gate. Optical imaging hardware has also been embedded to provide topographic detail of the neural tissue.
UR - http://www.scopus.com/inward/record.url?scp=77952384962&partnerID=8YFLogxK
U2 - 10.1109/cnna.2010.5430288
DO - 10.1109/cnna.2010.5430288
M3 - Conference contribution
AN - SCOPUS:77952384962
SN - 9781424466795
T3 - 2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010
BT - 2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010
PB - IEEE Computer Society
T2 - 2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010
Y2 - 3 February 2010 through 5 February 2010
ER -