A CMOS-based lab-on-chip array for the combined magnetic stimulation and opto-chemical sensing of neural tissue

Timothy G. Constandinou, Pantelis Georgiou, Themistoklis Prodromakis, Chris Toumazou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

This paper presents a novel CMOS-based labon-chip platform for non-contact magnetic stimulation and recording of neural tissue. The proposed system is the first of its kind to integrate magnetic-stimulation and optochemical sensing in a single pixel, tesselated to form an 8×8 array. Fabricated in a commercially-available 0.35μm CMOS technology, the system can be intrinsically used for both optical imaging and pH sensing and includes mechanisms for calibrating out sensor variation and mismatch. In addition to sensory acquisition via an integrated 10-bit ADC, a 64-instruction spatiotemporal pattern generator has been embedded within the array for driving the microscale magnetic neural stimulation. In this application the ISFET-based sensors are used to capacitively-couple neuronal charge in close proximity to the floating gate. Optical imaging hardware has also been embedded to provide topographic detail of the neural tissue.

Original languageEnglish
Title of host publication2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010
PublisherIEEE Computer Society
ISBN (Print)9781424466795
DOIs
Publication statusPublished - 29 Mar 2010
Event2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010 - Berkeley, CA, United States
Duration: 3 Feb 20105 Feb 2010

Publication series

Name2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010

Conference

Conference2010 12th International Workshop on Cellular Nanoscale Networks and their Applications, CNNA 2010
Country/TerritoryUnited States
CityBerkeley, CA
Period3/02/105/02/10

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