A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Alessandra Gambineri; Federica Tomassoni; Alessandra Munarini; Roland H Stimson; Roberto Mioni; Uberto Pagotto; Karen E Chapman; Ruth Andrew; Vilma Mantovani; Renato Pasquali; Brian R Walker

doi:10.1530/EJE-11-0091

A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Alessandra Gambineri, Federica Tomassoni, Alessandra Munarini, Roland H Stimson, Roberto Mioni, Uberto Pagotto, Karen E Chapman, Ruth Andrew, Vilma Mantovani, Renato Pasquali, Brian R Walker

Research output: Contribution to journal › Article › peer-review

Abstract

Regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11β-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS). However, the functional consequences of these SNPs for in vivo 11β-HSD1 expression and activity are unknown.

Original language	English
Pages (from-to)	283-92
Number of pages	10
Journal	European Journal of Endocrinology
Volume	165
Issue number	2
DOIs	https://doi.org/10.1530/EJE-11-0091
Publication status	Published - 2011

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Gambineri, A., Tomassoni, F., Munarini, A., Stimson, R. H., Mioni, R., Pagotto, U., Chapman, K. E., Andrew, R., Mantovani, V., Pasquali, R., & Walker, B. R. (2011). A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. European Journal of Endocrinology, 165(2), 283-92. https://doi.org/10.1530/EJE-11-0091

@article{d6bded2c37064e0d89e595ff6bd7568a,

title = "A combination of polymorphisms in HSD11B1 associates with in vivo 11\{beta\}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome",

abstract = "Regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11β-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS). However, the functional consequences of these SNPs for in vivo 11β-HSD1 expression and activity are unknown.",

author = "Alessandra Gambineri and Federica Tomassoni and Alessandra Munarini and Stimson, \{Roland H\} and Roberto Mioni and Uberto Pagotto and Chapman, \{Karen E\} and Ruth Andrew and Vilma Mantovani and Renato Pasquali and Walker, \{Brian R\}",

year = "2011",

doi = "10.1530/EJE-11-0091",

language = "English",

volume = "165",

pages = "283--92",

journal = "European Journal of Endocrinology",

issn = "1479-683X",

publisher = "Oxford University Press",

number = "2",

}

Gambineri, A, Tomassoni, F, Munarini, A, Stimson, RH, Mioni, R, Pagotto, U, Chapman, KE , Andrew, R, Mantovani, V, Pasquali, R & Walker, BR 2011, 'A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome', European Journal of Endocrinology, vol. 165, no. 2, pp. 283-92. https://doi.org/10.1530/EJE-11-0091

A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. / Gambineri, Alessandra; Tomassoni, Federica; Munarini, Alessandra et al.
In: European Journal of Endocrinology, Vol. 165, No. 2, 2011, p. 283-92.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

AU - Gambineri, Alessandra

AU - Tomassoni, Federica

AU - Munarini, Alessandra

AU - Stimson, Roland H

AU - Mioni, Roberto

AU - Pagotto, Uberto

AU - Chapman, Karen E

AU - Andrew, Ruth

AU - Mantovani, Vilma

AU - Pasquali, Renato

AU - Walker, Brian R

PY - 2011

Y1 - 2011

N2 - Regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11β-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS). However, the functional consequences of these SNPs for in vivo 11β-HSD1 expression and activity are unknown.

AB - Regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11β-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS). However, the functional consequences of these SNPs for in vivo 11β-HSD1 expression and activity are unknown.

U2 - 10.1530/EJE-11-0091

DO - 10.1530/EJE-11-0091

M3 - Article

C2 - 21622477

SN - 1479-683X

VL - 165

SP - 283

EP - 292

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 2

ER -

A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

Abstract

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