A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease

Lauren Elizabeth Walker, Michael John Griffiths, Fiona McGill, Penelope Lewthwaite, Graeme John Sills, Andrea L Jorgensen, Daniel James Antoine, Tom Solomon, Anthony Guy Marson, Munir Pirmohamed

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIMS: To determine whether a correlation exists between paired cerebrospinal fluid (CSF) and serum levels of a novel inflammatory biomarker, high-mobility group box 1 (HMGB1), in different neurological conditions.

METHODS: HMGB1 was measured in the serum and CSF of 46 neurological patients (18 idiopathic intracranial hypertension [IIH], 18 neurological infection/inflammation [NII] and 10 Rasmussen's encephalitis [RE]).

RESULTS: Mean serum (± SD) HMGB1 levels were 1.43 ± 0.54, 25.28 ± 27.9 and 1.89 ± 1.49 ng/ml for the patients with IIH, NII and RE, respectively. Corresponding mean (± SD) CSF levels were 0.35 ± 0.22, 4.48 ± 6.56 and 2.24 ± 2.35 ng/ml. Both CSF and serum HMGB1 was elevated in NII. Elevated CSF HMGB1 was demonstrated in RE. There was no direct correlation between CSF and serum levels of HMGB1.

CONCLUSION: Serum HMGB1 cannot be used as a surrogate measure for CSF levels. CSF HMGB1 was elevated in NII and RE, its role as a prognostic/stratification biomarker needs further study.

Original languageEnglish
Pages (from-to)635-642
Number of pages8
JournalBiomarkers
Volume22
Issue number7
Early online date30 Nov 2016
DOIs
Publication statusPublished - Nov 2017

Keywords / Materials (for Non-textual outputs)

  • Journal Article

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