Projects per year
Abstract
Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
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Original language | English |
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Pages (from-to) | 56-66 |
Number of pages | 11 |
Journal | Biochemical Pharmacology |
Volume | 86 |
Issue number | 1 |
Early online date | 10 Apr 2013 |
DOIs | |
Publication status | Published - 1 Jul 2013 |
Keywords / Materials (for Non-textual outputs)
- Cholesterol
- Sterol
- SBGN
- Metabolic network
- Pathway map
- ISOPENTENYL DIPHOSPHATE ISOMERASE
- MEVALONATE PYROPHOSPHATE DECARBOXYLASE
- CYTOCHROME P450 OXIDOREDUCTASE
- PEROXISOMAL TARGETING SIGNALS
- COA LYASE DEFICIENCY
- PHOSPHOMEVALONATE KINASE
- SQUALENE SYNTHASE
- NEURODEGENERATIVE DISEASES
- ISOPRENOID BIOSYNTHESIS
- ENDOPLASMIC-RETICULUM
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Dive into the research topics of 'A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway'. Together they form a unique fingerprint.Projects
- 1 Finished
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SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
8/01/07 → 31/12/12
Project: Research