A core outcome set for future research in ectopic pregnancy – an international consensus development study

Krystle Y. Chong; Sarah Solangon; Kurt Barnhart; Pamela Causa-Andrieu; Perrine Capmas; George Condous; Liesl De waard; James Mn. Duffy; Andrew W. Horne; Maria Memtsa; Femke Mol; Munira Oza; Romina Pesce; Annika Strandell; Madelon Van wely; Janneke Van ‘t Hooft; Lan N. Vuong; Jian Zhang; Davor Jurkovic; Ben W. Mol

doi:10.1016/j.fertnstert.2023.01.042

A core outcome set for future research in ectopic pregnancy – an international consensus development study

Krystle Y. Chong, Sarah Solangon, Kurt Barnhart, Pamela Causa-Andrieu, Perrine Capmas, George Condous, Liesl De waard, James Mn. Duffy, Andrew W. Horne, Maria Memtsa, Femke Mol, Munira Oza, Romina Pesce, Annika Strandell, Madelon Van wely, Janneke Van ‘t Hooft, Lan N. Vuong, Jian Zhang, Davor Jurkovic, Ben W. Mol

Research output: Contribution to journal › Article › peer-review

Abstract

Background
Randomised controlled trials (RCTs) evaluating ectopic pregnancy have different outcomes which are defined and measured in diverse ways, which limits their ability to inform evidence-based clinical practice.

Objective
To address methodological deficiencies in published RCTs and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy.

Design
To identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in ectopic pregnancy. Potential core outcomes were then entered into a three-round Delphi survey. 154 participants from six continents, comprising healthcare professionals, researchers, and individuals with lived experience in ectopic pregnancy, completed all three rounds of the Delphi survey. Outcomes were prioritised at three consensus development meetings and recommendations were developed on how to report these outcomes where possible.

Subjects
Healthcare professionals, researchers, and individuals with lived experience in ectopic pregnancy

Results
Six outcomes reached full consensus, including treatment success, resolution time, number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.

Conclusion
The core outcome set with six outcomes for ectopic pregnancy will help standardise reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient centred care.

Original language	English
Pages (from-to)	804-812
Journal	Fertility and Sterility
Volume	119
Issue number	5
Early online date	1 Feb 2023
DOIs	https://doi.org/10.1016/j.fertnstert.2023.01.042
Publication status	Published - May 2023

Keywords / Materials (for Non-textual outputs)

Core outcome set
consensus methods
ectopic pregnancy

Access to Document

10.1016/j.fertnstert.2023.01.042

EPCOS V6.2 - Jan 2023 CLEANAccepted author manuscript, 71.5 KB

https://linkinghub.elsevier.com/retrieve/pii/S0015028223000869

MRC Centre for Reproductive Health at the University of Edinburgh
Pollard, J.
MRC
12/09/16 → 11/09/22
Project: Research

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Chong, K. Y., Solangon, S., Barnhart, K., Causa-Andrieu, P., Capmas, P., Condous, G., De waard, L., Duffy, J. M., Horne, A. W., Memtsa, M., Mol, F., Oza, M., Pesce, R., Strandell, A., Van wely, M., Hooft, J. V. ., Vuong, L. N., Zhang, J., Jurkovic, D., & Mol, B. W. (2023). A core outcome set for future research in ectopic pregnancy – an international consensus development study. Fertility and Sterility, 119(5), 804-812. https://doi.org/10.1016/j.fertnstert.2023.01.042

@article{00206214f2824b6bbf7ae49f586134fa,

title = "A core outcome set for future research in ectopic pregnancy – an international consensus development study",

abstract = "BackgroundRandomised controlled trials (RCTs) evaluating ectopic pregnancy have different outcomes which are defined and measured in diverse ways, which limits their ability to inform evidence-based clinical practice.ObjectiveTo address methodological deficiencies in published RCTs and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy.DesignTo identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in ectopic pregnancy. Potential core outcomes were then entered into a three-round Delphi survey. 154 participants from six continents, comprising healthcare professionals, researchers, and individuals with lived experience in ectopic pregnancy, completed all three rounds of the Delphi survey. Outcomes were prioritised at three consensus development meetings and recommendations were developed on how to report these outcomes where possible.SubjectsHealthcare professionals, researchers, and individuals with lived experience in ectopic pregnancyResultsSix outcomes reached full consensus, including treatment success, resolution time, number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.ConclusionThe core outcome set with six outcomes for ectopic pregnancy will help standardise reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient centred care.",

keywords = "Core outcome set, consensus methods, ectopic pregnancy",

author = "Chong, {Krystle Y.} and Sarah Solangon and Kurt Barnhart and Pamela Causa-Andrieu and Perrine Capmas and George Condous and {De waard}, Liesl and Duffy, {James Mn.} and Horne, {Andrew W.} and Maria Memtsa and Femke Mol and Munira Oza and Romina Pesce and Annika Strandell and {Van wely}, Madelon and Hooft, {Janneke Van {\textquoteleft}t} and Vuong, {Lan N.} and Jian Zhang and Davor Jurkovic and Mol, {Ben W.}",

note = "Funding Information: K.Y.C. has nothing to disclose. S.S. has nothing to disclose. K.B. has nothing to disclose. P.C.-A. reports grants from the National Institutes of Health / National Cancer Institute Cancer Centre Support Grant P30 CA008748. P.C. has nothing to disclose. G.C. has nothing to disclose. L.d.W. has nothing to disclose. J.M.N.D. has nothing to disclose. A.W.H. has received honoraria for consultancy for Ferring , Roche , Nordic Pharma , and AbbVie . M.M. has nothing to disclose. F.M. has nothing to disclose. M.O. has nothing to disclose. R.P. has nothing to disclose. A.S. has nothing to disclose. M.v.W. reports leading the Netherlands Satellite of the Cochrane Gynaecology and Fertility Group. J.v.H. has nothing to disclose. L.N.V. reports other from Merck , grants and other from Merck Sharp and Dohme , and grants and other from Ferring , outside the submitted work. J.Z. has nothing to disclose. D.J. has nothing to disclose. B.W.M. reports grants from the National Health and National Health and Medical Research Council , other from ObsEva, and grants from Guerbet and Merck , outside the submitted work. Publisher Copyright: {\textcopyright} 2023 American Society for Reproductive Medicine",

year = "2023",

month = may,

doi = "10.1016/j.fertnstert.2023.01.042",

language = "English",

volume = "119",

pages = "804--812",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "5",

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Chong, KY, Solangon, S, Barnhart, K, Causa-Andrieu, P, Capmas, P, Condous, G, De waard, L, Duffy, JM, Horne, AW, Memtsa, M, Mol, F, Oza, M, Pesce, R, Strandell, A, Van wely, M, Hooft, JV, Vuong, LN, Zhang, J, Jurkovic, D & Mol, BW 2023, 'A core outcome set for future research in ectopic pregnancy – an international consensus development study', Fertility and Sterility, vol. 119, no. 5, pp. 804-812. https://doi.org/10.1016/j.fertnstert.2023.01.042

TY - JOUR

T1 - A core outcome set for future research in ectopic pregnancy – an international consensus development study

AU - Chong, Krystle Y.

AU - Solangon, Sarah

AU - Barnhart, Kurt

AU - Causa-Andrieu, Pamela

AU - Capmas, Perrine

AU - Condous, George

AU - De waard, Liesl

AU - Duffy, James Mn.

AU - Horne, Andrew W.

AU - Memtsa, Maria

AU - Mol, Femke

AU - Oza, Munira

AU - Pesce, Romina

AU - Strandell, Annika

AU - Van wely, Madelon

AU - Hooft, Janneke Van ‘t

AU - Vuong, Lan N.

AU - Zhang, Jian

AU - Jurkovic, Davor

AU - Mol, Ben W.

N1 - Funding Information: K.Y.C. has nothing to disclose. S.S. has nothing to disclose. K.B. has nothing to disclose. P.C.-A. reports grants from the National Institutes of Health / National Cancer Institute Cancer Centre Support Grant P30 CA008748. P.C. has nothing to disclose. G.C. has nothing to disclose. L.d.W. has nothing to disclose. J.M.N.D. has nothing to disclose. A.W.H. has received honoraria for consultancy for Ferring , Roche , Nordic Pharma , and AbbVie . M.M. has nothing to disclose. F.M. has nothing to disclose. M.O. has nothing to disclose. R.P. has nothing to disclose. A.S. has nothing to disclose. M.v.W. reports leading the Netherlands Satellite of the Cochrane Gynaecology and Fertility Group. J.v.H. has nothing to disclose. L.N.V. reports other from Merck , grants and other from Merck Sharp and Dohme , and grants and other from Ferring , outside the submitted work. J.Z. has nothing to disclose. D.J. has nothing to disclose. B.W.M. reports grants from the National Health and National Health and Medical Research Council , other from ObsEva, and grants from Guerbet and Merck , outside the submitted work. Publisher Copyright: © 2023 American Society for Reproductive Medicine

PY - 2023/5

Y1 - 2023/5

N2 - BackgroundRandomised controlled trials (RCTs) evaluating ectopic pregnancy have different outcomes which are defined and measured in diverse ways, which limits their ability to inform evidence-based clinical practice.ObjectiveTo address methodological deficiencies in published RCTs and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy.DesignTo identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in ectopic pregnancy. Potential core outcomes were then entered into a three-round Delphi survey. 154 participants from six continents, comprising healthcare professionals, researchers, and individuals with lived experience in ectopic pregnancy, completed all three rounds of the Delphi survey. Outcomes were prioritised at three consensus development meetings and recommendations were developed on how to report these outcomes where possible.SubjectsHealthcare professionals, researchers, and individuals with lived experience in ectopic pregnancyResultsSix outcomes reached full consensus, including treatment success, resolution time, number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.ConclusionThe core outcome set with six outcomes for ectopic pregnancy will help standardise reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient centred care.

AB - BackgroundRandomised controlled trials (RCTs) evaluating ectopic pregnancy have different outcomes which are defined and measured in diverse ways, which limits their ability to inform evidence-based clinical practice.ObjectiveTo address methodological deficiencies in published RCTs and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy.DesignTo identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in ectopic pregnancy. Potential core outcomes were then entered into a three-round Delphi survey. 154 participants from six continents, comprising healthcare professionals, researchers, and individuals with lived experience in ectopic pregnancy, completed all three rounds of the Delphi survey. Outcomes were prioritised at three consensus development meetings and recommendations were developed on how to report these outcomes where possible.SubjectsHealthcare professionals, researchers, and individuals with lived experience in ectopic pregnancyResultsSix outcomes reached full consensus, including treatment success, resolution time, number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.ConclusionThe core outcome set with six outcomes for ectopic pregnancy will help standardise reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient centred care.

KW - Core outcome set

KW - consensus methods

KW - ectopic pregnancy

U2 - 10.1016/j.fertnstert.2023.01.042

DO - 10.1016/j.fertnstert.2023.01.042

M3 - Article

SN - 0015-0282

VL - 119

SP - 804

EP - 812

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

A core outcome set for future research in ectopic pregnancy – an international consensus development study

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

MRC Centre for Reproductive Health at the University of Edinburgh

Cite this