A defect in insulin release in women at risk of future non-insulin-dependent diabetes

A Dornhorst, S G Edwards, J S Nicholls, V Anyaoku, D McLaren, K E Heslop, R S Elkeles, R W Beard, D G Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

1. A study on seven Caucasian glucose-tolerant women with previous gestational diabetes and seven matched control subjects is presented. The insulin response to oral glucose, insulin sensitivity and fasting glucose production rates were measured by using a 75 g oral glucose tolerance test, an insulin tolerance test and a non-radioactive tracer, [6,6-2H]glucose, respectively. 2. Fasting plasma glucose levels were similar between the women with previous gestational diabetes and the control subjects (4.8 +/- 0.3 versus 4.7 +/- 0.2 mmol/l), as were fasting plasma insulin levels (median 4 m-units/l, range 1-13 m-units/l versus median 4 m-units/l, range 1-24 m-units/l). After oral glucose the 60 min plasma glucose levels in the women with previous gestational diabetes were significantly higher (8.5 +/- 0.6 versus 6.7 +/- 0.8 mmol/l, P less than 0.05), whereas the plasma insulin level was significantly lower at both 30 min (median 23 m-units/l, range 4-47 m-units/l versus median 55 m-units/l, range 23-100 m-units/l, P less than 0.02) and at 60 min (median 23 m-units/l, range 4-43 m-units/l versus median 60 m-units/l, range 16-126 m-units/l, P less than 0.02). 3. Insulin sensitivity, expressed as the slope of the regression line of plasma glucose level against time after intravenous infusion of insulin (0.05 unit/kg), was similar in the women with previous gestational diabetes and the control subjects (mean slope, -0.17 +/- 0.01 versus -0.17 +/- 0.01). 4. Fasting glucose production rates were similar in the women with previous gestational diabetes and the control subjects (2.2 +/- 0.3 versus 1.9 +/- 0.1 mg min-1 kg-1).(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)195-9
Number of pages5
JournalClinical science
Volume81
Issue number2
Publication statusPublished - Aug 1991

Keywords

  • Adult
  • Blood Glucose/metabolism
  • Diabetes Mellitus, Type 2/etiology
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin/metabolism
  • Insulin Secretion
  • Pregnancy
  • Pregnancy in Diabetics/blood
  • Risk Factors
  • Time Factors

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