A developmental look at thymus organogenesis: Where do the non-hematopoietic cells in the thymus come from?

Nancy R. Manley*, C. Clare Blackburn

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The origins of the non-hematopoietic cell types that comprise the thymic stroma remain a topic of considerable controversy. Three recent studies, using lineage analysis and other methods to determine the developmental potential of specific cell types within the thymus, have provided strong evidence of a single endodermal origin for all thymic epithelial cells. Together with other investigations that merge immunological and developmental biology approaches, these studies have suggested a new model of thymus organogenesis, and have begun to uncover the molecular pathways that control this process.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalCurrent Opinion in Immunology
Volume15
Issue number2
DOIs
Publication statusPublished - 1 Jan 2003

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