A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt(IV) Prodrug Activation

Daniel Norman, Alessia Gambardella, Andrew Mount, Alan Murray, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

A Ruthenium-based mitochondrial-targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of Pt(IV) prodrugs into their active Pt(II) counterparts and drives the generation of singlet oxygen was designed. This duality drives two orthogonal killing mechanisms with cytotoxicity mediated with temporal and spatial control and was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin-resistance.
Original languageEnglish
Pages (from-to)14189-14192
Number of pages4
JournalAngewandte Chemie International Edition
Volume58
Issue number40
Early online date9 Aug 2019
DOIs
Publication statusPublished - 1 Oct 2019

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