TY - GEN
T1 - A dual switched-capacitor integrator architecture for versatile, real-time amperometric biosensing
AU - Pligouroudis, Michail
AU - Papadimitriou, Konstantinos I.
AU - Evans, Daniel
AU - Prodromakis, Themistoklis
N1 - Funding Information:
The authors acknowledge the financial support of the Engineering and Physical Sciences Research Council (EPSRC), EP/L020920/1 research grant.
Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/28
Y1 - 2017/9/28
N2 - In this paper, a versatile, re-programmable, current-input bioinstrumentation board is presented for electrochemical amperometric measurements. The proposed instrument has been fabricated on a six layer printed circuit board (PCB) and exploits dual switched-capacitor (SC) integration and sample-and-hold (SH) techniques. It comprises off-the-shelf switch and amplifier ICs and a commercially available FPGA-based DSP unit for digital signal control and synchronisation. It features eight amperometric channels, has a dynamic current range of 100dB, can be powered-up by a USB port or a 5V battery and is portable, with dimensions of 110×110 mm2. An onboard digital-to-analog converter (DAC) combined with standard three-electrode potentiostats can provide precise, programmable biasing voltages to eight amperometric biosensors simultaneously. Validation of the robustness and accuracy of the proposed system is demonstrated by proof-of-concept amperometric measurements using a high-precision Keithley 6221 current source and NaCI solution on a PCB-based sensor.
AB - In this paper, a versatile, re-programmable, current-input bioinstrumentation board is presented for electrochemical amperometric measurements. The proposed instrument has been fabricated on a six layer printed circuit board (PCB) and exploits dual switched-capacitor (SC) integration and sample-and-hold (SH) techniques. It comprises off-the-shelf switch and amplifier ICs and a commercially available FPGA-based DSP unit for digital signal control and synchronisation. It features eight amperometric channels, has a dynamic current range of 100dB, can be powered-up by a USB port or a 5V battery and is portable, with dimensions of 110×110 mm2. An onboard digital-to-analog converter (DAC) combined with standard three-electrode potentiostats can provide precise, programmable biasing voltages to eight amperometric biosensors simultaneously. Validation of the robustness and accuracy of the proposed system is demonstrated by proof-of-concept amperometric measurements using a high-precision Keithley 6221 current source and NaCI solution on a PCB-based sensor.
KW - Dual-Switched Capacitor Integration
KW - FPGA
KW - PCB-Based Sensor
KW - Point-of-Care Diagnostics
KW - Switched-Capacitor
UR - http://www.scopus.com/inward/record.url?scp=85032692018&partnerID=8YFLogxK
U2 - 10.1109/ISCAS.2017.8050728
DO - 10.1109/ISCAS.2017.8050728
M3 - Conference contribution
AN - SCOPUS:85032692018
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
BT - IEEE International Symposium on Circuits and Systems
PB - Institute of Electrical and Electronics Engineers
T2 - 50th IEEE International Symposium on Circuits and Systems, ISCAS 2017
Y2 - 28 May 2017 through 31 May 2017
ER -