A facile, inexpensive scalable route to α-methyl cysteine

Heather J Johnston, Alison N Hulme

Research output: Contribution to journalArticlepeer-review


A facile, scalable synthesis of α-methyl cysteine with three alternate thiol protecting groups (Trt, Allyl and tBu) is described. The thiol protected amino acids are obtained in 6 steps from L-cysteine ethyl ester and are ideally suited for a range of natural product and solid-phase peptide synthesis applications.
Original languageEnglish
Article numberST-2013-D0069-L
Pages (from-to)591-594
Number of pages4
JournalAccounts and Rapid Communications in Chemical Synthesis (SYNLETT)
Issue number5
Early online date25 Feb 2013
Publication statusPublished - Mar 2013


  • natural products
  • alpha methyl cysteine
  • solid phase peptide synthesis
  • camphor sultam auxiliary
  • P2-Et


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