A Feasibility Study of Quantifying longitudinal Brain Changes in Herpes simplex virus (HSV) Encephalitis using Magnetic Resonance Imaging (MRI) and stereology

Sylviane Defres, Simon S. Keller, kumar das, Rishma Vidyasagar, Laura M. Parkes, Girvan Burnside, Michael Griffiths, Michael Kopelman, John Roberts, Tom Solomon

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives
To assess whether it is feasible to quantify acute change in temporal lobe volume and total oedema volumes in herpes simplex virus (HSV) encephalitis as a preliminary to a trial of corticosteroid therapy.
Methods
The study analysed serially acquired magnetic resonance images (MRI), of patients with acute HSV encephalitis who had neuroimaging repeated within four weeks of the first scan. We performed volumetric measurements of the left and right temporal lobes and of cerebral oedema visible on T2 weighted Fluid Attenuated Inversion Recovery (FLAIR) images using stereology in conjunction with point counting.
Results
Temporal lobe volumes increased on average by 1.6% (standard deviation (SD 11%) in five patients who had not received corticosteroid therapy and decreased in two patients who had received corticosteroids by 8.5%. FLAIR hyperintensity volumes increased by 9% in patients not receiving treatment with corticosteroids and decreased by 29% in the two patients that had received corticosteroids.
Conclusions
This study has shown it is feasible to quantify acute change in temporal lobe and total oedema volumes in HSV encephalitis and suggests a potential resolution of swelling in response to corticosteroid therapy. These techniques could be used as part of a randomized control trial to investigate the efficacy of corticosteroids for treating HSV encephalitis in conjunction with assessing clinical outcomes and could be of potential value in helping to predict the clinical outcomes of patients with HSV encephalitis.
Original languageEnglish
JournalPLoS ONE
Early online date26 Jan 2017
DOIs
Publication statusE-pub ahead of print - 26 Jan 2017

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