A femtosecond laser inscribed biochip for stem cell therapeutic applications

D. Choudhury*, W. T. Ramsay, G. Brown, N. D. Psaila, S. Beecher, R. R. Thomson, R. Kiss, S. Pells, N. A. Willoughby, L. Paterson, A. K. Kar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

A continuous flow microfluidic cell separation platform has been designed and fabricated using femtosecond laser inscription. The device is a scalable and non-invasive cell separation mechanism aimed at separating human embryonic stem cells from differentiated cells based on the dissimilarities in their cytoskeletal elasticity. Successful demonstration of the device has been achieved using human leukemia cells the elasticity of which is similar to that of human embryonic stem cells.

Original languageEnglish
Title of host publicationMICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS IX
EditorsH Becker, BL Gray
Place of PublicationBELLINGHAM
PublisherSPIE
Number of pages6
DOIs
Publication statusPublished - 2011
EventConference on Microfluidics, BioMEMS, and Medical Microsystems IX - San Francisco, Canada
Duration: 23 Jan 201125 Jan 2011

Publication series

NameProceedings of SPIE
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Volume7929
ISSN (Print)0277-786X

Conference

ConferenceConference on Microfluidics, BioMEMS, and Medical Microsystems IX
Country/TerritoryCanada
Period23/01/1125/01/11

Keywords / Materials (for Non-textual outputs)

  • femtosecond laser inscription
  • chemical etching
  • cell separation
  • cell sorting
  • fused silica
  • human embryonic stem cells
  • FUSED-SILICA
  • SORTER
  • SEPARATION
  • EXPRESSION
  • CHIP

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