Abstract
Many difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often simple to predict. Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe small effects.
| Original language | English |
|---|---|
| Article number | 27 |
| Journal | BMC Systems Biology |
| Volume | 3 |
| DOIs | |
| Publication status | Published - 2009 |
Keywords / Materials (for Non-textual outputs)
- Adaptation, Biological
- Algorithms
- Biological Evolution
- Genetics, Population
- Genomics
- Models, Genetic
- Mutation
- Systems Biology
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Dive into the research topics of 'A framework for evolutionary systems biology'. Together they form a unique fingerprint.Projects
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SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A. (Principal Investigator), Beggs, J. (Co-investigator), Ghazal, P. (Co-investigator), Goryanin, I. (Co-investigator), Hillston, J. (Co-investigator), Plotkin, G. (Co-investigator), Tollervey, D. (Co-investigator), Walton, A. (Co-investigator) & Robertson, K. (Researcher)
Biotechnology and Biological Sciences Research Council
8/01/07 → 31/12/12
Project: Research
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