A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

E Katz; S Dubois-Marshall; Andrew Sims; D Faratian; J Li; E S Smith; J A Quinn; M Edward; R R Meehan; E E Evans; S P Langdon; D J Harrison

doi:10.1038/sj.bjc.6605763

A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

E Katz, S Dubois-Marshall, Andrew Sims, D Faratian, J Li, E S Smith, J A Quinn, M Edward, R R Meehan, E E Evans, S P Langdon, D J Harrison

Research output: Contribution to journal › Article › peer-review

Abstract

C35 is a 12 kDa membrane-anchored protein endogenously over-expressed in many invasive breast cancers. C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 in invasive breast cancer is unknown.

Original language	English
Pages (from-to)	401-10
Number of pages	10
Journal	British Journal of Cancer
Volume	103
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjc.6605763
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

breast cancer
C35
HER2
epithelial to mesenchymal transition
ITAM
Syk kinase

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10.1038/sj.bjc.6605763

Katz et al 2010
BJC Open
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Katz, E., Dubois-Marshall, S., Sims, A., Faratian, D., Li, J., Smith, E. S., Quinn, J. A., Edward, M., Meehan, R. R., Evans, E. E., Langdon, S. P., & Harrison, D. J. (2010). A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. British Journal of Cancer, 103(3), 401-10. https://doi.org/10.1038/sj.bjc.6605763

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AU - Katz, E

AU - Dubois-Marshall, S

AU - Sims, Andrew

AU - Faratian, D

AU - Li, J

AU - Smith, E S

AU - Quinn, J A

AU - Edward, M

AU - Meehan, R R

AU - Evans, E E

AU - Langdon, S P

AU - Harrison, D J

PY - 2010

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AB - C35 is a 12 kDa membrane-anchored protein endogenously over-expressed in many invasive breast cancers. C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 in invasive breast cancer is unknown.

KW - breast cancer

KW - C35

KW - HER2

KW - epithelial to mesenchymal transition

KW - ITAM

KW - Syk kinase

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DO - 10.1038/sj.bjc.6605763

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A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

Abstract

Keywords / Materials (for Non-textual outputs)

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