A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

E Katz, S Dubois-Marshall, Andrew Sims, D Faratian, J Li, E S Smith, J A Quinn, M Edward, R R Meehan, E E Evans, S P Langdon, D J Harrison

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

C35 is a 12 kDa membrane-anchored protein endogenously over-expressed in many invasive breast cancers. C35 (C17orf37) is located on the HER2 amplicon, between HER2 and GRB7. The function of over-expressed C35 in invasive breast cancer is unknown.
Original languageEnglish
Pages (from-to)401-10
Number of pages10
JournalBritish Journal of Cancer
Volume103
Issue number3
DOIs
Publication statusPublished - 2010

Keywords / Materials (for Non-textual outputs)

  • breast cancer
  • C35
  • HER2
  • epithelial to mesenchymal transition
  • ITAM
  • Syk kinase

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