A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Sarah E. Harris; Helen Fox; Alan F. Wright; Caroline Hayward; John Starr; Lawrence J. Whalley; Ian J. Deary

doi:10.1186/1471-2156-8-43

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Sarah E. Harris, Helen Fox, Alan F. Wright, Caroline Hayward, John Starr, Lawrence J. Whalley, Ian J. Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing.

Results: Associations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive association were then genotyped in a second cohort for whom we have cognitive ability scores at the ages of 11 and 64 years (ABC1936). An intronic SNP in the APP gene (rs2830102) was significantly associated with cognitive ageing in both LBC1921 and a combined LBC1921/ABC1936 analysis (p < 0.01), but not in ABC1936 alone.

Conclusion: This study suggests a possible role for APP in normal cognitive ageing, in addition to its role in Alzheimer's disease.

Original language	English
Article number	43
Pages (from-to)	-
Number of pages	18
Journal	BMC Genetics
Volume	8
DOIs	https://doi.org/10.1186/1471-2156-8-43
Publication status	Published - 2 Jul 2007

Keywords / Materials (for Non-textual outputs)

SINGLE-NUCLEOTIDE POLYMORPHISMS
ONSET ALZHEIMERS-DISEASE
SCOTTISH MENTAL SURVEY
AMYLOID-BETA PEPTIDE
DIFFERENTIAL EXPRESSION
MESSENGER-RNAS
CATHEPSIN-D
FOLLOW-UP
AGE
BRAIN

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10.1186/1471-2156-8-43

C:\Users\sbates2\psych 3\A genetic association analysis
©Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J., Whalley, L. J., & Deary, I. J. (2007). A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. BMC Genetics, 8, -[43]doi: 10.1186/1471-2156-8-43
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Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress
Deary, I. (Principal Investigator) & Starr, J. (Co-investigator)
BBSRC
1/03/03 → 31/03/10
Project: Research

Cite this

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title = "A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition",

abstract = "Background: Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing.Results: Associations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive association were then genotyped in a second cohort for whom we have cognitive ability scores at the ages of 11 and 64 years (ABC1936). An intronic SNP in the APP gene (rs2830102) was significantly associated with cognitive ageing in both LBC1921 and a combined LBC1921/ABC1936 analysis (p < 0.01), but not in ABC1936 alone.Conclusion: This study suggests a possible role for APP in normal cognitive ageing, in addition to its role in Alzheimer's disease.",

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author = "Harris, {Sarah E.} and Helen Fox and Wright, {Alan F.} and Caroline Hayward and John Starr and Whalley, {Lawrence J.} and Deary, {Ian J.}",

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AU - Harris, Sarah E.

AU - Fox, Helen

AU - Wright, Alan F.

AU - Hayward, Caroline

AU - Starr, John

AU - Whalley, Lawrence J.

AU - Deary, Ian J.

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N2 - Background: Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing.Results: Associations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive association were then genotyped in a second cohort for whom we have cognitive ability scores at the ages of 11 and 64 years (ABC1936). An intronic SNP in the APP gene (rs2830102) was significantly associated with cognitive ageing in both LBC1921 and a combined LBC1921/ABC1936 analysis (p < 0.01), but not in ABC1936 alone.Conclusion: This study suggests a possible role for APP in normal cognitive ageing, in addition to its role in Alzheimer's disease.

AB - Background: Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing.Results: Associations between cognitive ageing and 325 single nucleotide polymorphisms (SNPs), located in 109 genes implicated in oxidative stress and/or cognition, were examined in a unique cohort of relatively healthy older people, on whom we have cognitive ability scores at ages 11 and 79 years (LBC1921). SNPs showing a significant positive association were then genotyped in a second cohort for whom we have cognitive ability scores at the ages of 11 and 64 years (ABC1936). An intronic SNP in the APP gene (rs2830102) was significantly associated with cognitive ageing in both LBC1921 and a combined LBC1921/ABC1936 analysis (p < 0.01), but not in ABC1936 alone.Conclusion: This study suggests a possible role for APP in normal cognitive ageing, in addition to its role in Alzheimer's disease.

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KW - SCOTTISH MENTAL SURVEY

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KW - DIFFERENTIAL EXPRESSION

KW - MESSENGER-RNAS

KW - CATHEPSIN-D

KW - FOLLOW-UP

KW - AGE

KW - BRAIN

U2 - 10.1186/1471-2156-8-43

DO - 10.1186/1471-2156-8-43

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JF - BMC Genetics

M1 - 43

ER -

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Abstract

Keywords / Materials (for Non-textual outputs)

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Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress

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