A genetic link between type 2 diabetes and prostate cancer

T. M. Frayling, H. Colhoun, J. C. Florez

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

Original languageEnglish
Pages (from-to)1757-1760
Number of pages4
JournalDiabetologia
Volume51
Issue number10
DOIs
Publication statusPublished - 2008

Keywords

  • Epidemiology Genes Genome-wide association study Pleiotropy Prostate cancer Transcription factors Type 2 diabetes Genome-wide association Metabolic syndrome Reduced risk US men Variants Mellitus Mutations Multiple Loci Susceptibility

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