Abstract
Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.
| Original language | English |
|---|---|
| Pages (from-to) | 1757-1760 |
| Number of pages | 4 |
| Journal | Diabetologia |
| Volume | 51 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords / Materials (for Non-textual outputs)
- Epidemiology Genes Genome-wide association study Pleiotropy Prostate cancer Transcription factors Type 2 diabetes Genome-wide association Metabolic syndrome Reduced risk US men Variants Mellitus Mutations Multiple Loci Susceptibility