A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project

Fabio Marroni, Arne Pfeufer, Yurii S Aulchenko, Christopher S Franklin, Aaron Isaacs, Irene Pichler, Sarah H Wild, Ben A Oostra, Alan F Wright, Harry Campbell, Jacqueline C Witteman, Stefan Kääb, Andrew A Hicks, Ulf Gyllensten, Igor Rudan, Thomas Meitinger, Cristian Pattaro, Cornelia M van Duijn, James F Wilson, Peter P PramstallerEUROSPAN Consortium

Research output: Contribution to journalArticlepeer-review

Abstract

We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.
Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.

Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)
Original languageEnglish
Pages (from-to)322-8
Number of pages7
JournalCirculation: Cardiovascular Genetics
Volume2
Issue number4
DOIs
Publication statusPublished - Aug 2009

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