A genome-wide association study for reading and language abilities in two population cohorts

Michelle Luciano, David M Evans, Narelle K Hansell, Sarah E Medland, Grant W Montgomery, Nicholas G Martin, Margaret J Wright, Timothy C Bates

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12 to 25 years (n = 1,177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5,472). Suggestive association was indicated for reading measures and non-word repetition, with the greatest support found for SNPs in the pseudogene, ABCC13 (p = 7.34 x10(-8) ), and the gene, DAZAP1 (p = 1.32 x10(-6) ). Gene-based analyses showed significant association (p 
Original languageEnglish
Pages (from-to)645-652
Number of pages8
JournalGenes, Brain and Behavior
Volume12
Issue number6
Early online date5 Jun 2013
DOIs
Publication statusPublished - Aug 2013

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