Abstract / Description of output
Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12 to 25 years (n = 1,177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5,472). Suggestive association was indicated for reading measures and non-word repetition, with the greatest support found for SNPs in the pseudogene, ABCC13 (p = 7.34 x10(-8) ), and the gene, DAZAP1 (p = 1.32 x10(-6) ). Gene-based analyses showed significant association (p
Original language | English |
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Pages (from-to) | 645-652 |
Number of pages | 8 |
Journal | Genes, Brain and Behavior |
Volume | 12 |
Issue number | 6 |
Early online date | 5 Jun 2013 |
DOIs | |
Publication status | Published - Aug 2013 |