A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

W Meng, A Veluchamy, H L Hébert, A Campbell, H M Colhoun, C N A Palmer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.

OBJECTIVES: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.

METHODS: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.

RESULTS: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10(-8) . The narrow-sense heritability of this phenotype is 0.06.

CONCLUSIONS: We suggest that the MAPK14 gene is associated with DFU. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalBritish journal of dermatology
Early online date3 Jul 2017
DOIs
Publication statusE-pub ahead of print - 3 Jul 2017

Keywords / Materials (for Non-textual outputs)

  • Journal Article

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