A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p

D Posthuma, M Luciano, E J C de Geus, M J Wright, P E Slagboom, G W Montgomery, D I Boomsma, N G Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Between 40% and 80% of the variation in human intelligence ( IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 ( LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.

Original languageEnglish
Pages (from-to)318-326
Number of pages9
JournalAmerican Journal of Human Genetics
Volume77
Issue number2
Publication statusPublished - Aug 2005

Keywords

  • GENERAL COGNITIVE-ABILITY
  • READING-DISABILITY
  • CHROMOSOME 6P
  • ASSOCIATION ANALYSIS
  • GENETIC DISSECTION
  • CANDIDATE GENES
  • DNA MARKERS
  • WIDE SCAN
  • LINKAGE
  • AUTISM

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