A Glial Signal Consisting of Gliomedin and NrCAM Clusters Axonal Na+ Channels during the Formation of Nodes of Ranvier

Konstantin Feinberg, Yael Eshed-Eisenbach, Shahar Frechter, Veronique Amor, Daniela Salomon, Helena Sabanay, Jeffrey L. Dupree, Martin Grumet, Peter J. Brophy, Peter Shrager, Elior Peles

Research output: Contribution to journalArticlepeer-review

Abstract

Saltatory conduction requires high-density accumulation of Na+ channels at the nodes of Ranvier. Nodal Na+ channel clustering in the peripheral nervous system is regulated by myelinating Schwann cells through unknown mechanisms. During development, Na+ channels are first clustered at heminodes that border each myelin segment, and later in the mature nodes that are formed by the fusion of two heminodes. Here, we show that initial clustering of Na+ channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186). We further demonstrate that heminodal clustering coincides with a second, paranodal junction (PNJ)-dependent mechanism that allows Na+ channels to accumulate at mature nodes by restricting their distribution between two growing myelin internodes. We propose that Schwann cells assemble the nodes of Ranvier by capturing Na+ channels at heminodes and by constraining their distribution to the nodal gap. Together, these two cooperating mechanisms ensure fast and efficient conduction in myelinated nerves.

Original languageEnglish
Pages (from-to)490-502
Number of pages13
JournalNeuron
Volume65
Issue number4
DOIs
Publication statusPublished - 25 Feb 2010

Keywords

  • molneuro

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