Projects per year
Abstract / Description of output
expression atlas and assign those signatures, where possible, to specific cell populations or pathways. The findings are related to innate immunity by focusing on clusters with an immune signature, and to the advantages of cross-breeding by examining the patterns of genes exhibiting the greatest expression differences between purebred and crossbred animals. This high-resolution gene expression atlas for sheep is, to our knowledge, the largest transcriptomic dataset from any livestock species to date. It provides a resource to improve the annotation of the current reference genome for sheep, presenting a model transcriptome for ruminants and insight into gene, cell and tissue function at multiple developmental stages.
Original language | English |
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Article number | e1006997 |
Journal | PLoS Genetics |
Volume | 13 |
Issue number | 9 |
DOIs | |
Publication status | Published - 15 Sept 2017 |
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Dive into the research topics of 'A high resolution atlas of gene expression in the domestic sheep (Ovis aries)'. Together they form a unique fingerprint.Projects
- 4 Finished
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Functional Annotation of the Sheep Genome
Hume, D., Archibald, A., Morrison, I., Summers, K. & Watson, M.
16/10/13 → 3/05/17
Project: Research
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Future-Proofing the sustainability of the MRC high throughput sequencing hub in Scotland
Blaxter, M.
1/10/12 → 30/09/14
Project: Research
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Research output
- 1 Working paper
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Elimination of reference mapping bias reveals robust immune related allele-specific expression in cross-bred sheep
Salavati, M., Bush, S., Palma-Vera, S., McCulloch, M., Hume, D. & Clark, E., 25 Apr 2019, (E-pub ahead of print) bioRxiv, at Cold Spring Harbor Laboratory, (bioRxiv).Research output: Working paper
File
Datasets
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A high resolution atlas of gene expression in the domestic sheep (Ovis aries)
Clark, E. (Creator), Bush, S. (Creator), McCulloch, M. (Creator), Farquhar, I. (Creator), Young, R. (Creator), Lefevre, L. (Creator), Pridans, C. (Creator), Tsang, H. (Creator), Wu, C. (Creator), Afrasiabi, C. (Creator), Watson, M. (Creator), Whitelaw, B. (Creator), Freeman, T. (Creator), Summers, K. (Creator), Archibald, A. (Creator) & Hume, D. (Creator), Edinburgh DataShare, 10 Aug 2017
DOI: 10.7488/ds/2112
Dataset
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Unnormalised raw count estimates for the sheep gene expression atlas dataset
Hume, D. A. (Creator), Bush, S. (Creator) & Clark, E. (Creator), Edinburgh DataShare, 28 Aug 2019
DOI: 10.7488/ds/2616, https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006997
Dataset
Profiles
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Emily Clark
Person: Academic: Research Active (Research Assistant)