Projects per year
Abstract / Description of output
expression atlas and assign those signatures, where possible, to specific cell populations or pathways. The findings are related to innate immunity by focusing on clusters with an immune signature, and to the advantages of cross-breeding by examining the patterns of genes exhibiting the greatest expression differences between purebred and crossbred animals. This high-resolution gene expression atlas for sheep is, to our knowledge, the largest transcriptomic dataset from any livestock species to date. It provides a resource to improve the annotation of the current reference genome for sheep, presenting a model transcriptome for ruminants and insight into gene, cell and tissue function at multiple developmental stages.
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- 4 Finished
1/10/12 → 30/09/14
- 1 Working paper
Elimination of reference mapping bias reveals robust immune related allele-specific expression in cross-bred sheepSalavati, M., Bush, S., Palma-Vera, S., McCulloch, M., Hume, D. & Clark, E., 25 Apr 2019, (E-pub ahead of print) bioRxiv, at Cold Spring Harbor Laboratory, (bioRxiv).
Research output: Working paperFile
Clark, E. (Creator), Bush, S. (Creator), McCulloch, M. (Creator), Farquhar, I. (Creator), Young, R. (Creator), Lefevre, L. (Creator), Pridans, C. (Creator), Tsang, H. (Creator), Wu, C. (Creator), Afrasiabi, C. (Creator), Watson, M. (Creator), Whitelaw, B. (Creator), Freeman, T. (Creator), Summers, K. (Creator), Archibald, A. (Creator) & Hume, D. (Creator), Edinburgh DataShare, 10 Aug 2017
Hume, D. A. (Creator), Bush, S. (Creator) & Clark, E. (Creator), Edinburgh DataShare, 28 Aug 2019