TY - JOUR
T1 - A highly potent and cellularly active beta-peptidic inhibitor of the p53/hDM2 interaction
AU - Hintersteiner, Martin
AU - Kimmerlin, Thierry
AU - Garavel, Geraldine
AU - Schindler, Thorsten
AU - Bauer, Roman
AU - Meisner, Nicole-Claudia
AU - Seifert, Jan-Marcus
AU - Uhl, Volker
AU - Auer, Manfred
PY - 2009/4/14
Y1 - 2009/4/14
N2 - New and improved : The incorporation of a 6‐chlorotryptophan (6‐Cl‐Trp) into a β‐peptide (M)‐314 helix leads to a high‐affinity hDM2 inhibitor, as demonstrated by fluorescence fluctuation analysis at single molecule resolution. When conjugated to penetratin, the newly derived hDM2 binder specifically inhibits tumour cell growth in vitro.
AB - New and improved : The incorporation of a 6‐chlorotryptophan (6‐Cl‐Trp) into a β‐peptide (M)‐314 helix leads to a high‐affinity hDM2 inhibitor, as demonstrated by fluorescence fluctuation analysis at single molecule resolution. When conjugated to penetratin, the newly derived hDM2 binder specifically inhibits tumour cell growth in vitro.
U2 - 10.1002/cbic.200800803
DO - 10.1002/cbic.200800803
M3 - Article
SN - 1439-4227
VL - 10
SP - 994
EP - 998
JO - ChemBioChem
JF - ChemBioChem
IS - 6
ER -