A highly potent and cellularly active beta-peptidic inhibitor of the p53/hDM2 interaction

Martin Hintersteiner, Thierry Kimmerlin, Geraldine Garavel, Thorsten Schindler, Roman Bauer, Nicole-Claudia Meisner, Jan-Marcus Seifert, Volker Uhl, Manfred Auer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

New and improved : The incorporation of a 6‐chlorotryptophan (6‐Cl‐Trp) into a β‐peptide (M)‐314 helix leads to a high‐affinity hDM2 inhibitor, as demonstrated by fluorescence fluctuation analysis at single molecule resolution. When conjugated to penetratin, the newly derived hDM2 binder specifically inhibits tumour cell growth in vitro.

Original languageEnglish
Pages (from-to)994-998
Number of pages5
JournalChemBioChem
Volume10
Issue number6
DOIs
Publication statusPublished - 14 Apr 2009

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