A highly prevalent and genetically diversified Picornaviridae genus in South Asian children

Amit Kapoor, Joseph Victoria, Peter Simmonds, Elizabeth Slikas, Thaweesak Chieochansin, Asif Naeem, Shahzad Shaukat, Salmaan Sharif, Muhammad Masroor Alam, Mehar Angez, Chunlin Wang, Robert W Shafer, Sohail Zaidi, Eric Delwart

Research output: Contribution to journalArticlepeer-review

Abstract

Viral metagenomics focused on particle-protected nucleic acids was used on the stools of South Asian children with nonpolio acute flaccid paralysis (AFP). We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to characterize multiple viral species within a previously unreported genus of the Picornaviridae family. The picornaviruses were detected in the stools of >40% of AFP and healthy Pakistani children. A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was therefore identified substantially expanding the genetic diversity of the RNA viral flora commonly found in children.
Original languageEnglish
Pages (from-to)20482-7
Number of pages6
JournalProceedings of the National Academy of Sciences
Volume105
Issue number51
DOIs
Publication statusPublished - Dec 2008

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