A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

Yogeswari Chandran; Nam-Young  Kang; Sung-Jin Park; Samira Husen Alamudi; Jun-Young Kim; Srikanta  Sahu; Dongdong Su; Jungyeol  Lee; Marc Vendrell; Young-Tae Chang

doi:10.1016/j.bmcl.2015.06.037

A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

Yogeswari Chandran, Nam-Young Kang, Sung-Jin Park, Samira Husen Alamudi, Jun-Young Kim, Srikanta Sahu, Dongdong Su, Jungyeol Lee, Marc Vendrell, Young-Tae Chang

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	25
Issue number	21
Early online date	16 Jun 2015
DOIs	https://doi.org/10.1016/j.bmcl.2015.06.037
Publication status	Published - 1 Nov 2015

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10.1016/j.bmcl.2015.06.037

A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
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http://www.sciencedirect.com/science/article/pii/S0960894X15006307

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J.
MRC
1/09/12 → 31/08/16
Project: Research

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title = "A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells",

abstract = "Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.",

author = "Yogeswari Chandran and Nam-Young Kang and Sung-Jin Park and Alamudi, {Samira Husen} and Jun-Young Kim and Srikanta Sahu and Dongdong Su and Jungyeol Lee and Marc Vendrell and Young-Tae Chang",

note = "Open Access funded by Medical Research Council",

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doi = "10.1016/j.bmcl.2015.06.037",

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T1 - A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

AU - Chandran, Yogeswari

AU - Kang, Nam-Young

AU - Park, Sung-Jin

AU - Alamudi, Samira Husen

AU - Kim, Jun-Young

AU - Sahu, Srikanta

AU - Su, Dongdong

AU - Lee, Jungyeol

AU - Vendrell, Marc

AU - Chang, Young-Tae

N1 - Open Access funded by Medical Research Council

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.

AB - Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.

U2 - 10.1016/j.bmcl.2015.06.037

DO - 10.1016/j.bmcl.2015.06.037

M3 - Article

VL - 25

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 21

ER -

A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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