A Highly Selective Fluorescent Probe for Direct Detection and Isolation of Mouse Embryonic Stem Cells

Yogeswari Chandran, Nam-Young Kang, Sung-Jin Park, Samira Husen Alamudi, Jun-Young Kim, Srikanta Sahu, Dongdong Su, Jungyeol Lee, Marc Vendrell, Young-Tae Chang

Research output: Contribution to journalArticlepeer-review

Abstract

Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume25
Issue number21
Early online date16 Jun 2015
DOIs
Publication statusPublished - 1 Nov 2015

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