A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Liyun Zhang; Jun Cheng Er; Hao Jiang; Xin Li; Zhaofeng Luo; Thomas Ramezani; Yi Feng; Mui Kee Tang; Young-Tae Chang; Marc Vendrell

doi:10.1039/c6cc00095a

A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Liyun Zhang, Jun Cheng Er, Hao Jiang, Xin Li, Zhaofeng Luo, Thomas Ramezani, Yi Feng, Mui Kee Tang, Young-Tae Chang, Marc Vendrell

Research output: Contribution to journal › Article › peer-review

Abstract

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/c6cc00095a
Publication status	Published - 4 Mar 2016

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ENDOIMAGE - Activatable Fluorescent Probes as Smart Diagnostic Tools for Microendoscopy Imaging
Vendrell Escobar, M.
EU other
1/08/13 → 31/07/17
Project: Research

Yi Feng
- yi.feng@ed.ac.uk
Person: Academic: Research Active

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title = "A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase",

abstract = "Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.",

author = "Liyun Zhang and Er, {Jun Cheng} and Hao Jiang and Xin Li and Zhaofeng Luo and Thomas Ramezani and Yi Feng and Tang, {Mui Kee} and Young-Tae Chang and Marc Vendrell",

year = "2016",

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doi = "10.1039/c6cc00095a",

language = "English",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

AU - Zhang, Liyun

AU - Er, Jun Cheng

AU - Jiang, Hao

AU - Li, Xin

AU - Luo, Zhaofeng

AU - Ramezani, Thomas

AU - Feng, Yi

AU - Tang, Mui Kee

AU - Chang, Young-Tae

AU - Vendrell, Marc

PY - 2016/3/4

Y1 - 2016/3/4

N2 - Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

AB - Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

U2 - 10.1039/c6cc00095a

DO - 10.1039/c6cc00095a

M3 - Article

C2 - 26940443

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

ER -

A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Abstract

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