A highly sensitive fluorescent viscosity sensor

Rahimi M. Yusop; Asier Unciti-Broceta; Mark Bradley

doi:10.1016/j.bmcl.2012.07.101

A highly sensitive fluorescent viscosity sensor

Rahimi M. Yusop^*, Asier Unciti-Broceta, Mark Bradley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

Original language	English
Pages (from-to)	5780-5783
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	22
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2012.07.101
Publication status	Published - 15 Sept 2012

Keywords / Materials (for Non-textual outputs)

BIOLOGY
DYES
MICROSPHERES
Fluorescein
Palladium catalysis
LIVING CELLS
PROBES
Viscosity sensor
Suzuki cross-coupling
MOLECULAR ROTORS
CHEMISTRY
Anthofluorescein
SINGLE-CELL

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10.1016/j.bmcl.2012.07.101

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@article{fc907c4370b048328b923bf7befe8a71,

title = "A highly sensitive fluorescent viscosity sensor",

abstract = "Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.",

keywords = "BIOLOGY, DYES, MICROSPHERES, Fluorescein, Palladium catalysis, LIVING CELLS, PROBES, Viscosity sensor, Suzuki cross-coupling, MOLECULAR ROTORS, CHEMISTRY, Anthofluorescein, SINGLE-CELL",

author = "Yusop, {Rahimi M.} and Asier Unciti-Broceta and Mark Bradley",

year = "2012",

month = sep,

day = "15",

doi = "10.1016/j.bmcl.2012.07.101",

language = "English",

volume = "22",

pages = "5780--5783",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "18",

}

TY - JOUR

T1 - A highly sensitive fluorescent viscosity sensor

AU - Yusop, Rahimi M.

AU - Unciti-Broceta, Asier

AU - Bradley, Mark

PY - 2012/9/15

Y1 - 2012/9/15

N2 - Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

AB - Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

KW - BIOLOGY

KW - DYES

KW - MICROSPHERES

KW - Fluorescein

KW - Palladium catalysis

KW - LIVING CELLS

KW - PROBES

KW - Viscosity sensor

KW - Suzuki cross-coupling

KW - MOLECULAR ROTORS

KW - CHEMISTRY

KW - Anthofluorescein

KW - SINGLE-CELL

U2 - 10.1016/j.bmcl.2012.07.101

DO - 10.1016/j.bmcl.2012.07.101

M3 - Article

SN - 0960-894X

VL - 22

SP - 5780

EP - 5783

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 18

ER -

A highly sensitive fluorescent viscosity sensor

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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