A highly sensitive fluorescent viscosity sensor

Rahimi M. Yusop*, Asier Unciti-Broceta, Mark Bradley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

Original languageEnglish
Pages (from-to)5780-5783
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume22
Issue number18
DOIs
Publication statusPublished - 15 Sep 2012

Keywords

  • BIOLOGY
  • DYES
  • MICROSPHERES
  • Fluorescein
  • Palladium catalysis
  • LIVING CELLS
  • PROBES
  • Viscosity sensor
  • Suzuki cross-coupling
  • MOLECULAR ROTORS
  • CHEMISTRY
  • Anthofluorescein
  • SINGLE-CELL

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