A joint less ordinary: intriguing roles for Hedgehog signalling in the development and maturation of the temporomandibular synovial joint

Malgorzata Kubiak, Mark Ditzel

Research output: Contribution to journalArticlepeer-review

Abstract

This review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps involved in formation of a temporomandibular joint (TMJ). We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associated Oncogene Homolog (GLI) dependent and independent functions. Morphogenesis and maturation of the TMJ’s individual components and the general landscape of Hh signalling is also covered. Comparison of the appendicular knee and axial TMJ also reveals interesting differences and similarities in their mechanisms of development, chondrogenesis and reliance on Hh signalling.
Original languageEnglish
JournalJournal of Developmental Biology
DOIs
Publication statusPublished - 26 Aug 2016

Keywords

  • Hedgehog
  • Hh
  • Indian Hedgehog
  • IHH
  • temporomandibular joint
  • synovial joint
  • GLI

Fingerprint

Dive into the research topics of 'A joint less ordinary: intriguing roles for Hedgehog signalling in the development and maturation of the temporomandibular synovial joint'. Together they form a unique fingerprint.

Cite this