A key mechanism of pathogenesis in sheep infected with the nematode Teladorsagia circumcincta

M J Stear, S C Bishop, N G Henderson, I Scott

Research output: Contribution to journalArticlepeer-review

Abstract

Infection of sheep with the abomasal nematode Teladorsagia circumcincta can cause a relative protein deficiency and reduce growth rate in growing lambs. A key event appears to be the destruction of junctions between epithelial cells. If the infection is heavy or prolonged, this leads to increased mucus production, hyperplasia, decreased acid production, gastrinemia, inappetance and pepsinogenemia. The severity of the infection depends upon the extent of concurrent infection, the nutritional status of the host and genetically controlled variation in the ability to mount protective immune responses.
Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalAnimal Health Research Reviews
Volume4
Issue number1
DOIs
Publication statusPublished - Jun 2003

Keywords

  • Abomasum
  • Animals
  • Nematoda
  • Nematode Infections
  • Severity of Illness Index
  • Sheep
  • Sheep Diseases

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