A lateral flow assay (LFA) for the rapid detection of extraparenchymal neurocysticercosis using cerebrospinal fluid

Agnes Fleury, Patricia Sastre, Edda Sciutto, Silvia Correia, Alejandro Monedero, Andrea Toledo, Maricela Hernandez, Leslie J.s. Harrison, R. Michael E. Parkhouse

Research output: Contribution to journalArticlepeer-review

Abstract

A lateral flow assay (LFA) for the diagnosis and monitoring of extraparenchymal neurocysticercosis, has been developed. The assay is based on the use of the monoclonal antibody HP10, and when applied to cerebrospinal fluid, correctly identified 34 cases of active extraparenchymal neurocysticercosis, but was negative with 26 samples from treated and cured neurocysticercosis patients and with 20 samples from unrelated neurological diseases. There was complete agreement between the HP10 Ag-ELISA results and the HP10-LFA. The HP10-LFA thus has utility for diagnosis and treatment of extraparenchymal neurocysticercosis, frequently a more dangerous form of the infection.
Original languageEnglish
Pages (from-to)67-70
JournalExperimental Parasitology
Volume171
Early online date28 Oct 2016
DOIs
Publication statusE-pub ahead of print - 28 Oct 2016

Keywords

  • Extraparenchymal neurocysticercosis
  • Diagnosis
  • Lateral flow assay
  • Taenia
  • HP10
  • NTD

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