A leap into the unknown: Early events in African Trypanosome transmission

Balázs Szöőr, Eleanor Silvester, Keith R Matthews

Research output: Contribution to journalReview articlepeer-review

Abstract

African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.

Original languageEnglish
Pages (from-to)266-278
JournalTrends in Parasitology
Volume36
Issue number3
Early online date31 Jan 2020
DOIs
Publication statusE-pub ahead of print - 31 Jan 2020

Keywords

  • Trypanosoma brucei
  • Trypanosoma congolense
  • development and differentiation
  • signaling
  • gene expression
  • tsetse fly

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