A leap into the unknown: Early events in African Trypanosome transmission

Balázs Szöőr; Eleanor Silvester; Keith R Matthews

doi:10.1016/j.pt.2019.12.011

A leap into the unknown: Early events in African Trypanosome transmission

Balázs Szöőr, Eleanor Silvester, Keith R Matthews

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.

Original language	English
Pages (from-to)	266-278
Journal	Trends in Parasitology
Volume	36
Issue number	3
Early online date	31 Jan 2020
DOIs	https://doi.org/10.1016/j.pt.2019.12.011
Publication status	E-pub ahead of print - 31 Jan 2020

Keywords

Trypanosoma brucei
Trypanosoma congolense
development and differentiation
signaling
gene expression
tsetse fly

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10.1016/j.pt.2019.12.011Licence: Creative Commons: Attribution (CC-BY)

MatthewsEtalTPA2020LeapIntoTheUnknownEarlyEventsInAfricanFinal published version, 1.44 MBLicence: Creative Commons: Attribution (CC-BY)

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1 Active

Environmental sensing and cell-cell communication in African trypanosomes
Matthews, K.
UK-based charities
1/04/15 → 30/09/21
Project: Research

Cite this

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title = "A leap into the unknown: Early events in African Trypanosome transmission",

abstract = "African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.",

keywords = "Trypanosoma brucei, Trypanosoma congolense, development and differentiation, signaling, gene expression, tsetse fly",

author = "Bal{\'a}zs Sz{\"o}{\H o}r and Eleanor Silvester and Matthews, {Keith R}",

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T2 - Early events in African Trypanosome transmission

AU - Szöőr, Balázs

AU - Silvester, Eleanor

AU - Matthews, Keith R

PY - 2020/1/31

Y1 - 2020/1/31

N2 - African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.

AB - African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.

KW - Trypanosoma brucei

KW - Trypanosoma congolense

KW - development and differentiation

KW - signaling

KW - gene expression

KW - tsetse fly

U2 - 10.1016/j.pt.2019.12.011

DO - 10.1016/j.pt.2019.12.011

M3 - Review article

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VL - 36

SP - 266

EP - 278

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 3

ER -

A leap into the unknown: Early events in African Trypanosome transmission

Abstract

Keywords

Access to Document

Environmental sensing and cell-cell communication in African trypanosomes

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