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Abstract
African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.
Original language | English |
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Pages (from-to) | 266-278 |
Journal | Trends in Parasitology |
Volume | 36 |
Issue number | 3 |
Early online date | 31 Jan 2020 |
DOIs | |
Publication status | E-pub ahead of print - 31 Jan 2020 |
Keywords
- Trypanosoma brucei
- Trypanosoma congolense
- development and differentiation
- signaling
- gene expression
- tsetse fly
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Dive into the research topics of 'A leap into the unknown: Early events in African Trypanosome transmission'. Together they form a unique fingerprint.Projects
- 1 Finished
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Environmental sensing and cell-cell communication in African trypanosomes
1/04/15 → 31/01/22
Project: Research