A lesson on induction of hypothermia and measurement of efficacy

Bridget A Harris, Peter J D Andrews

Research output: Contribution to journalComment/debate

Abstract

Brain injuries caused by stroke are common and costly in human and resource terms. The result of stroke is a cascade of molecular and physiological derangement, cell death, damage and inflammation in the brain. This, together with infection, if present, commonly results in patients having an increased temperature, which is associated with worse outcome. The usual clinical goal in stroke is therefore to reduce temperature to normal, or below normal (hypothermia) to reduce swelling if brain pressure is increased. However, research evidence does not yet conclusively show whether or not cooling patients after stroke improves their longer-term outcome (reduces death and disability). It is possible that complications of cooling outweigh the benefits. Cooling therapy may reduce damage and potentially improve outcome, and head cooling targets the site of injury and may have fewer side effects than systemic cooling, but the evidence base is unclear.

Original languageEnglish
Pages (from-to)710
JournalCritical Care
Volume18
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Brain
  • Humans
  • Hypothermia, Induced
  • Nasopharynx
  • Stroke

Fingerprint

Dive into the research topics of 'A lesson on induction of hypothermia and measurement of efficacy'. Together they form a unique fingerprint.

Cite this