Projects per year
Abstract / Description of output
Aging is a set of complex processes that occur temporally and continuously. It is generally a unidirectional progression of cellular and molecular changes occurring during the life stages of cells, tissues and ultimately the whole organism. In vertebrate organisms, this begins at conception from the first steps in blastocyst formation, gastrulation, germ layer differentiation, and organogenesis to a continuum of embryonic, fetal, adolescent, adult, and geriatric stages. Tales of the "fountain of youth" and songs of being "forever young" are dominant ideas informing us that growing old is something science should strive to counteract. Here, we discuss the normal life stages of the blood system, particularly the historical recognition of its importance in the early growth stages of vertebrates, and what this means with respect to progressive gain and loss of hematopoietic function in the adult.
Original language | English |
---|---|
Pages (from-to) | 2755-2764 |
Journal | FEBS Letters |
Volume | 598 |
Issue number | 22 |
DOIs | |
Publication status | Published - 5 Mar 2024 |
Keywords / Materials (for Non-textual outputs)
- aging
- development
- fate
- hematopoiesis
- hemogenic endothelial cell
- Aging/physiology
- Animals
- Humans
- Hematopoiesis/physiology
- Hematopoietic Stem Cells/cytology
Fingerprint
Dive into the research topics of 'A life-time of hematopoietic cell function: ascent, stability, and decline'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Does GPR56 confer self-renewal properties on human hematopoietic stem cells and leukemic stem cells?
1/11/18 → 31/10/21
Project: Research