Abstract / Description of output
In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac (YS), which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte (MK) colony-forming cells belong to the conventional hematopoietic progenitor cell (HPC) compartment. Although these cells are indeed capable of generating polyploid MKs, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the YS in parallel to HPCs but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage.
Original language | English |
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Pages (from-to) | 2725-2729 |
Number of pages | 5 |
Journal | Blood |
Volume | 124 |
Issue number | 17 |
DOIs | |
Publication status | Published - 23 Oct 2014 |
Keywords / Materials (for Non-textual outputs)
- blood platelets
- diploidy
- embryo
- meckel-gruber syndrome
- megakaryocytes
- mice
- polyploidy
- proplatelet
- stem cells
- hematopoietic stem cells