A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza, Kevin Robertson, Paul A Lacaze, David Page, Anton J Enright, Peter Ghazal, Tom Freeman

Research output: Contribution to journalArticlepeer-review

Abstract

The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.
Original languageEnglish
Article number36
JournalBMC Systems Biology
Volume2
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Audiovisual Aids
  • Bone Marrow
  • Cells, Cultured
  • Computer Graphics
  • Immunity, Innate
  • Interferons
  • Logic
  • Macrophage Activation
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Models, Biological
  • Monocytes
  • NF-kappa B
  • Protein Interaction Mapping
  • Signal Transduction
  • Systems Biology
  • Systems Integration
  • Toll-Like Receptors
  • p38 Mitogen-Activated Protein Kinases

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