A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza; Kevin Robertson; Paul A Lacaze; David Page; Anton J Enright; Peter Ghazal; Tom Freeman

doi:10.1186/1752-0509-2-36

A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza, Kevin Robertson, Paul A Lacaze, David Page, Anton J Enright, Peter Ghazal, Tom Freeman

Research output: Contribution to journal › Article › peer-review

Abstract

The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.

Original language	English
Article number	36
Journal	BMC Systems Biology
Volume	2
DOIs	https://doi.org/10.1186/1752-0509-2-36
Publication status	Published - 2008

Keywords / Materials (for Non-textual outputs)

Animals
Audiovisual Aids
Bone Marrow
Cells, Cultured
Computer Graphics
Immunity, Innate
Interferons
Logic
Macrophage Activation
Male
Mice
Mice, Inbred BALB C
Models, Biological
Monocytes
NF-kappa B
Protein Interaction Mapping
Signal Transduction
Systems Biology
Systems Integration
Toll-Like Receptors
p38 Mitogen-Activated Protein Kinases

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10.1186/1752-0509-2-36

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Cite this

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abstract = "The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.",

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AU - Lacaze, Paul A

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AU - Enright, Anton J

AU - Ghazal, Peter

AU - Freeman, Tom

PY - 2008

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A logic-based diagram of signalling pathways central to macrophage activation

Abstract

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SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

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A logic-based diagram of signalling pathways central to macrophage activation

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Other files and links

Fingerprint

Projects

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

Cite this