A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza; Kevin Robertson; Paul A Lacaze; David Page; Anton J Enright; Peter Ghazal; Tom Freeman

doi:10.1186/1752-0509-2-36

A logic-based diagram of signalling pathways central to macrophage activation

Sobia Raza, Kevin Robertson, Paul A Lacaze, David Page, Anton J Enright, Peter Ghazal, Tom Freeman

Research output: Contribution to journal › Article › peer-review

Abstract

The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.

Original language	English
Article number	36
Journal	BMC Systems Biology
Volume	2
DOIs	https://doi.org/10.1186/1752-0509-2-36
Publication status	Published - 2008

Keywords

Animals
Audiovisual Aids
Bone Marrow
Cells, Cultured
Computer Graphics
Immunity, Innate
Interferons
Logic
Macrophage Activation
Male
Mice
Mice, Inbred BALB C
Models, Biological
Monocytes
NF-kappa B
Protein Interaction Mapping
Signal Transduction
Systems Biology
Systems Integration
Toll-Like Receptors
p38 Mitogen-Activated Protein Kinases

Access to Document

10.1186/1752-0509-2-36

PDF available here
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 2.1 MB

Cite this

@article{fd4e22a015524d389b24a0168c21908a,

title = "A logic-based diagram of signalling pathways central to macrophage activation",

abstract = "The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.",

keywords = "Animals, Audiovisual Aids, Bone Marrow, Cells, Cultured, Computer Graphics, Immunity, Innate, Interferons, Logic, Macrophage Activation, Male, Mice, Mice, Inbred BALB C, Models, Biological, Monocytes, NF-kappa B, Protein Interaction Mapping, Signal Transduction, Systems Biology, Systems Integration, Toll-Like Receptors, p38 Mitogen-Activated Protein Kinases",

author = "Sobia Raza and Kevin Robertson and Lacaze, {Paul A} and David Page and Enright, {Anton J} and Peter Ghazal and Tom Freeman",

year = "2008",

doi = "10.1186/1752-0509-2-36",

language = "English",

volume = "2",

journal = "BMC Systems Biology",

issn = "1752-0509",

publisher = "BioMed Central",

}

TY - JOUR

T1 - A logic-based diagram of signalling pathways central to macrophage activation

AU - Raza, Sobia

AU - Robertson, Kevin

AU - Lacaze, Paul A

AU - Page, David

AU - Enright, Anton J

AU - Ghazal, Peter

AU - Freeman, Tom

PY - 2008

Y1 - 2008

N2 - The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.

AB - The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions.

KW - Animals

KW - Audiovisual Aids

KW - Bone Marrow

KW - Cells, Cultured

KW - Computer Graphics

KW - Immunity, Innate

KW - Interferons

KW - Logic

KW - Macrophage Activation

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Models, Biological

KW - Monocytes

KW - NF-kappa B

KW - Protein Interaction Mapping

KW - Signal Transduction

KW - Systems Biology

KW - Systems Integration

KW - Toll-Like Receptors

KW - p38 Mitogen-Activated Protein Kinases

UR - http://www.scopus.com/inward/record.url?scp=44049087861&partnerID=8YFLogxK

U2 - 10.1186/1752-0509-2-36

DO - 10.1186/1752-0509-2-36

M3 - Article

C2 - 18433497

VL - 2

JO - BMC Systems Biology

JF - BMC Systems Biology

SN - 1752-0509

M1 - 36

ER -

A logic-based diagram of signalling pathways central to macrophage activation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

Cite this

A logic-based diagram of signalling pathways central to macrophage activation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

Cite this